Abstract
The glycosylation of inactive glycosyl donors, such as methyl glycosides and 1-hydroxy sugars with nearly stoichiometric amounts of various alcohols (1.1 equiv) in an ionic liquid containing a protic acid (acid-IL) under reduced pressure conditions proceeded effectively to give the corresponding glycosides in good to high yields. Furthermore, the acid-IL could be reused for additional glycosylations without the loss of efficiency.
| Original language | English |
|---|---|
| Pages (from-to) | 6294-6297 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 51 |
| Issue number | 48 |
| DOIs | |
| Publication status | Published - 2010 Dec 1 |
Keywords
- Glycosylation
- Green chemistry
- Inactive sugar
- Ionic liquids
- Reduced pressure
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry
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Cite this
Kuroiwa, Y., Sekine, M., Tomono, S., Takahashi, D., & Toshima, K. (2010). A novel glycosylation of inactive glycosyl donors using an ionic liquid containing a protic acid under reduced pressure conditions. Tetrahedron Letters, 51(48), 6294-6297. https://doi.org/10.1016/j.tetlet.2010.09.108