A novel glycosylation of inactive glycosyl donors using an ionic liquid containing a protic acid under reduced pressure conditions

Yasutaka Kuroiwa, Maiko Sekine, Satoshi Tomono, Daisuke Takahashi, Kazunobu Toshima

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12 Citations (Scopus)

Abstract

The glycosylation of inactive glycosyl donors, such as methyl glycosides and 1-hydroxy sugars with nearly stoichiometric amounts of various alcohols (1.1 equiv) in an ionic liquid containing a protic acid (acid-IL) under reduced pressure conditions proceeded effectively to give the corresponding glycosides in good to high yields. Furthermore, the acid-IL could be reused for additional glycosylations without the loss of efficiency.

Original languageEnglish
Pages (from-to)6294-6297
Number of pages4
JournalTetrahedron Letters
Volume51
Issue number48
DOIs
Publication statusPublished - 2010 Dec 1

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Keywords

  • Glycosylation
  • Green chemistry
  • Inactive sugar
  • Ionic liquids
  • Reduced pressure

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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