A novel greener glycosidation using an acid-ionic liquid containing a protic acid

Kaname Sasaki, Hideyuki Nagai, Shuichi Matsumura, Kazunobu Toshima

Research output: Contribution to journalArticle

56 Citations (Scopus)


The glycosidations of glucopyranosyl diethyl phosphite and alcohols using an ionic liquid, 1-n-hexyl-3-methylimidazolium trifluoromethanesulfonimidide (C6mim[NTf2]) containing a protic acid, trifluoromethanesulfonimide (HNTf2), as a novel solvent-catalyst system, effectively proceeded under mild conditions to give the corresponding glycosides in good to high yields. Furthermore, this acid-ionic liquid combination could be reused many times for the glycosidations without any loss in efficiency.

Original languageEnglish
Pages (from-to)5605-5608
Number of pages4
JournalTetrahedron Letters
Issue number30
Publication statusPublished - 2003 Jul 21



  • Diethyl phosphite
  • Glycosidation
  • Green chemistry
  • Ionic liquid
  • Protic acid

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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