TY - JOUR
T1 - A Novel Laser Fiberscope for Simultaneous Imaging and Phototherapy of Peripheral Lung Cancer
AU - Kinoshita, Tomonari
AU - Effat, Andrew
AU - Gregor, Alexander
AU - Inage, Terunaga
AU - Ishiwata, Tsukasa
AU - Motooka, Yamato
AU - Ujiie, Hideki
AU - Wilson, Brian C.
AU - Zheng, Gang
AU - Weersink, Robert
AU - Asamura, Hisao
AU - Yasufuku, Kazuhiro
N1 - Funding Information:
FUNDING/SUPPORT: This research was funded by the Canadian Cancer Society Research Institute [Grant 704123], the Terry Fox Research Institute [Grant 1075], the Canadian Institute of Health Research [Grant 154326], and the National Sanitarium Association, Innovative Research Program Grant 2018. Author contributions: K. Y. is the guarantor of this paper and takes responsibility for the integrity of all work in this paper. T. K. H. U. A. G. Y. M. T. I. T. I. and A. E. made substantial contributions to conception and design, or acquisition of data, or analysis and interpretation of data. T. K. R. W. B. C. W. G. Z. H. A. and K. Y. drafted the submitted article or revised it critically for important intellectual content, and provided final approval of the version to be published. All authors have agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. Financial/nonfinancial disclosures: None declared. Role of sponsors: The sponsor had no role in the design of the study, the collection and analysis of the data, or the preparation of the manuscript. Collaborators: Nicholas Bernards, PhD, Kosuke Fujino, MD, Chang Young Lee, MD, and Zhenchian Chen, MD (Division of Thoracic Surgery, Toronto General Hospital, University Health Network, Toronto, ON, Canada); Juan Chen, PhD, Lili Ding, MD, and Harley Chan, PhD (Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada); Kiyoshi Oka, PhD, and Sachiko Minakawa (OK Fiber Technology Co, Ltd, Kizugawa, Kyoto, Japan); and Takeshi Seki, PhD (Mechanical Engineering Course, Department of Systems Design Engineering, Graduate School of Engineering Science, Akita University, Akita, Japan). Other contributions: We thank Mss Kimberley Hudson, Patrycja Bauer, Judy McConnell, and Alexandria Grindlay (Toronto General Hospital) for laboratory management and Mr Harry Sakata, BE, for his experiment management support. Additional information: The e-Figures can be found in the Supplemental Materials section of the online article.
Funding Information:
FUNDING/SUPPORT: This research was funded by the Canadian Cancer Society Research Institute [Grant 704123], the Terry Fox Research Institute [Grant 1075], the Canadian Institute of Health Research [Grant 154326], and the National Sanitarium Association, Innovative Research Program Grant 2018. FUNDING/SUPPORT: This research was funded by the Canadian Cancer Society Research Institute [Grant 704123], the Terry Fox Research Institute [Grant 1075], the Canadian Institute of Health Research [Grant 154326], and the National Sanitarium Association, Innovative Research Program Grant 2018. Author contributions: K. Y. is the guarantor of this paper and takes responsibility for the integrity of all work in this paper. T. K. H. U. A. G. Y. M. T. I. T. I. and A. E. made substantial contributions to conception and design, or acquisition of data, or analysis and interpretation of data. T. K. R. W. B. C. W. G. Z. H. A. and K. Y. drafted the submitted article or revised it critically for important intellectual content, and provided final approval of the version to be published. All authors have agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. Financial/nonfinancial disclosures: None declared. Role of sponsors: The sponsor had no role in the design of the study, the collection and analysis of the data, or the preparation of the manuscript. Collaborators: Nicholas Bernards, PhD, Kosuke Fujino, MD, Chang Young Lee, MD, and Zhenchian Chen, MD (Division of Thoracic Surgery, Toronto General Hospital, University Health Network, Toronto, ON, Canada); Juan Chen, PhD, Lili Ding, MD, and Harley Chan, PhD (Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada); Kiyoshi Oka, PhD, and Sachiko Minakawa (OK Fiber Technology Co, Ltd, Kizugawa, Kyoto, Japan); and Takeshi Seki, PhD (Mechanical Engineering Course, Department of Systems Design Engineering, Graduate School of Engineering Science, Akita University, Akita, Japan). Other contributions: We thank Mss Kimberley Hudson, Patrycja Bauer, Judy McConnell, and Alexandria Grindlay (Toronto General Hospital) for laboratory management and Mr Harry Sakata, BE, for his experiment management support. Additional information: The e-Figures can be found in the Supplemental Materials section of the online article. FUNDING/SUPPORT: This research was funded by the Canadian Cancer Society Research Institute [Grant 704123], the Terry Fox Research Institute [Grant 1075], the Canadian Institute of Health Research [Grant 154326], and the National Sanitarium Association, Innovative Research Program Grant 2018.
Publisher Copyright:
© 2019 American College of Chest Physicians
PY - 2019/9
Y1 - 2019/9
N2 - Background: Phototherapy is an alternative treatment for patients with localized non-small cell lung cancer who are unable to undergo surgical resection. However, phototherapy is currently limited to treatment of centrally located lung cancer, with the much larger proportion of peripheral lesions remaining inaccessible. There are also concerns over the accuracy of targeted laser treatment because of the need to exchange visualization and irradiation fibers during therapy, preventing the operator from confirming the final location of the irradiation fiber. Methods: A newly developed parallel-type ultrasmall composite optical fiberscope (Laser-eYe Ultrathin fiberscope [LYU]), which enables simultaneous white-light imaging and phototherapy, was evaluated in preclinical lung cancer models. Three models were used: human lung cancer xenografts (A549) in mice, orthotopic VX2 lung tumors in rabbits, and ex vivo pig lungs into which A549 tumor tissue was transplanted. A multifunctional porphyrin-phospholipid nanoparticle (porphysome) was used as a photosensitizer to evaluate fluorescence-guided photothermal therapy. Results: The LYU's 0.97 mm diameter and hydrophilic coating allowed easy passage through the working channel of all types of bronchoscopes and controlled guidance of the LYU tip in any desired direction. The LYU could visualize the peripheral bronchus and porphysome-laden peripheral tumors. The LYU could also perform photothermal therapy with simultaneous imaging. Conclusions: The LYU enables simultaneous imaging and phototherapy that allows accurate irradiation of peripheral lung cancers. This new laser device may enable ultraminimally invasive transbronchial treatment of peripheral lung cancer.
AB - Background: Phototherapy is an alternative treatment for patients with localized non-small cell lung cancer who are unable to undergo surgical resection. However, phototherapy is currently limited to treatment of centrally located lung cancer, with the much larger proportion of peripheral lesions remaining inaccessible. There are also concerns over the accuracy of targeted laser treatment because of the need to exchange visualization and irradiation fibers during therapy, preventing the operator from confirming the final location of the irradiation fiber. Methods: A newly developed parallel-type ultrasmall composite optical fiberscope (Laser-eYe Ultrathin fiberscope [LYU]), which enables simultaneous white-light imaging and phototherapy, was evaluated in preclinical lung cancer models. Three models were used: human lung cancer xenografts (A549) in mice, orthotopic VX2 lung tumors in rabbits, and ex vivo pig lungs into which A549 tumor tissue was transplanted. A multifunctional porphyrin-phospholipid nanoparticle (porphysome) was used as a photosensitizer to evaluate fluorescence-guided photothermal therapy. Results: The LYU's 0.97 mm diameter and hydrophilic coating allowed easy passage through the working channel of all types of bronchoscopes and controlled guidance of the LYU tip in any desired direction. The LYU could visualize the peripheral bronchus and porphysome-laden peripheral tumors. The LYU could also perform photothermal therapy with simultaneous imaging. Conclusions: The LYU enables simultaneous imaging and phototherapy that allows accurate irradiation of peripheral lung cancers. This new laser device may enable ultraminimally invasive transbronchial treatment of peripheral lung cancer.
KW - composite fiberscope
KW - nanoparticle
KW - peripheral lung cancer
KW - phototherapy
UR - http://www.scopus.com/inward/record.url?scp=85067278390&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85067278390&partnerID=8YFLogxK
U2 - 10.1016/j.chest.2019.04.010
DO - 10.1016/j.chest.2019.04.010
M3 - Article
C2 - 31034817
AN - SCOPUS:85067278390
SN - 0012-3692
VL - 156
SP - 571
EP - 578
JO - Diseases of the chest
JF - Diseases of the chest
IS - 3
ER -
