A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity

Asuka Terashima, Hiroshi Watarai, Sayo Inoue, Etsuko Sekine, Ryusuke Nakagawa, Koji Hase, Chiaki Iwamura, Hiroshi Nakajima, Toshinori Nakayama, Masaru Taniguchi

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Abstract

Airway hypersensitive reaction (AHR) is an animal model for asthma, which is caused or enhanced by environmental factors such as allergen exposure. However, the precise mechanisms that drive AHR remain unclear. We identified a novel subset of natural killer T (NKT) cells that expresses the interleukin 17 receptor B (IL-17RB) for IL-25 (also known as IL-17E) and is essential for the induction of AHR. IL-17RB is preferentially expressed on a fraction of CD4 + NKT cells but not on other splenic leukocyte populations tested. IL-17RB+ CD4+ NKT cells produce predominantly IL-13 and Th2 chemokines upon stimulation with IL-25 in vitro. IL-17RB+ NKT cells were detected in the lung, and depletion of IL-17RB+ NKT cells by IL-17RB-specific monoclonal antibodies or NKT cell- deficient Jα18-/- mice failed to develop IL-25-dependent AHR. Cell transfer of IL-17RB+ but not IL-17RB" NKT cells into Jαa18-/- mice also successfully reconstituted AHR induction. These results strongly suggest that IL-17RB + CD4+ NKT cells play a crucial role in the pathogenesis of asthma.

Original languageEnglish
Pages (from-to)2727-2733
Number of pages7
JournalJournal of Experimental Medicine
Volume205
Issue number12
DOIs
Publication statusPublished - 2008 Nov 12

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Terashima, A., Watarai, H., Inoue, S., Sekine, E., Nakagawa, R., Hase, K., Iwamura, C., Nakajima, H., Nakayama, T., & Taniguchi, M. (2008). A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity. Journal of Experimental Medicine, 205(12), 2727-2733. https://doi.org/10.1084/jem.20080698