This paper proposes a novel time-delay compensation method for multi degree-of-freedom bilateral control system with different configuration. Bilateral control is a remote control technology, which enables transmission of force sensation. Time-delay is the one of the problems of the bilateral control, because it degrades the transparency and stability of the control system. Communication disturbance observer (CDOB) has been proposed to compensate time-delay without dead time model. However, CDOB cannot compensate time-delay if the bilateral control system has different configuration and is controlled in work space. Therefore, this paper proposes a novel observer, work space communication disturbance observer (WCDOB), for time-delay compensation. The proposed method can compensate time-delay if the bilateral control system has different configuration and is controlled in work space. Experiments were conducted by using actual network. The experimental results show the validity of the proposed method.