A novel treatment for refractory primary biliary cirrhosis?

S. Miyaguchi, H. Ebinuma, H. Imaeda, Y. Nitta, T. Watanabe, H. Saito, H. Ishii

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Background/Aims: Bezafibrate is naturally used for hyperlipidemia worldwide. In 1992 Day et al reported that the value of ALP and γ-GTP in hyperlipidemia declined aider administering bezafibrate orally. We conducted a study to investigate whether or not ALP and γ-GTP in primary biliary cirrhosis which is characterized by the elevation of these enzymes improved aider taking bezafibrate. Methodology: We administered bezafibrate additionally for 6 months to 13 patients with primary biliary cirrhosis (refractory PBC) whose liver enzymes (ALP or γ-GTP) did not renan within normal range out of 21 patients treated by monotherapy of ursodeoxycholic acid for 18 months. Results: At 2, 4, and 6 months, γ-GTP level significantly decreased compared with that prior to the initiation of bezafibrate. At and 6 months, ALP level significantly decreased compared with that prior to the initiation. At 2, 4 and 6 months, ALT level significantly decreased compared with that prior to the initiation. The value of IgG and IgM was also reduced significantly 6 months after the initiation. Conclusions: If the effectiveness of bezafibrate for primary biliary cirrhosis is confirmed histologically and by a randomized trial, a combination therapy of bezafibrate and ursodeoxycholic acid appear to be the medical treatment of choice for primary biliary cirrhosis in the future.

Original languageEnglish
Pages (from-to)1518-1521
Number of pages4
JournalHepato-gastroenterology
Volume47
Issue number36
Publication statusPublished - 2000 Dec 27

Keywords

  • Bezafibrate
  • PBC

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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    Miyaguchi, S., Ebinuma, H., Imaeda, H., Nitta, Y., Watanabe, T., Saito, H., & Ishii, H. (2000). A novel treatment for refractory primary biliary cirrhosis? Hepato-gastroenterology, 47(36), 1518-1521.