A paired microflap array for single cell interaction analysis

T. Teshima, K. Kuribayashi-Shigetomi, H. Onoe, T. Tonooka, S. Takeuchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We propose a microflap array system for producing cell membrane contact at single cell level. Microflaps, composed of Parylene and Permalloy, function as the magnet-active flapping actuators. Single cells are cultured onto each microflap. Cell-cultured microflap can be lifted up to make cell-to-cell contact by applying a magnetic field or with the assistance of glass capillary manipulation. By using this device, two single adherent cells can be paired without detaching cells from substrates. This proposed pairing system is expected to facilitate the analysis of cell-cell communication between two or more single adherent cells.

Original languageEnglish
Title of host publication15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Pages1704-1706
Number of pages3
Publication statusPublished - 2011 Dec 1
Externally publishedYes
Event15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States
Duration: 2011 Oct 22011 Oct 6

Publication series

Name15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Volume3

Other

Other15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
CountryUnited States
CitySeattle, WA
Period11/10/211/10/6

Keywords

  • Cell pairing
  • Cell-cell communication
  • Magnetic response
  • Microflap
  • Parylene

ASJC Scopus subject areas

  • Control and Systems Engineering

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  • Cite this

    Teshima, T., Kuribayashi-Shigetomi, K., Onoe, H., Tonooka, T., & Takeuchi, S. (2011). A paired microflap array for single cell interaction analysis. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 (pp. 1704-1706). (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011; Vol. 3).