TY - GEN
T1 - A paired microflap array for single cell interaction analysis
AU - Teshima, T.
AU - Kuribayashi-Shigetomi, K.
AU - Onoe, H.
AU - Tonooka, T.
AU - Takeuchi, S.
PY - 2011/12/1
Y1 - 2011/12/1
N2 - We propose a microflap array system for producing cell membrane contact at single cell level. Microflaps, composed of Parylene and Permalloy, function as the magnet-active flapping actuators. Single cells are cultured onto each microflap. Cell-cultured microflap can be lifted up to make cell-to-cell contact by applying a magnetic field or with the assistance of glass capillary manipulation. By using this device, two single adherent cells can be paired without detaching cells from substrates. This proposed pairing system is expected to facilitate the analysis of cell-cell communication between two or more single adherent cells.
AB - We propose a microflap array system for producing cell membrane contact at single cell level. Microflaps, composed of Parylene and Permalloy, function as the magnet-active flapping actuators. Single cells are cultured onto each microflap. Cell-cultured microflap can be lifted up to make cell-to-cell contact by applying a magnetic field or with the assistance of glass capillary manipulation. By using this device, two single adherent cells can be paired without detaching cells from substrates. This proposed pairing system is expected to facilitate the analysis of cell-cell communication between two or more single adherent cells.
KW - Cell pairing
KW - Cell-cell communication
KW - Magnetic response
KW - Microflap
KW - Parylene
UR - http://www.scopus.com/inward/record.url?scp=84883812491&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84883812491&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84883812491
SN - 9781618395955
T3 - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
SP - 1704
EP - 1706
BT - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
T2 - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Y2 - 2 October 2011 through 6 October 2011
ER -