A patient with elderly-onset atypical hydroa vacciniforme with an indolent clinical course

Hisashi Nomura, H. Suzuki, S. Egami, T. Yokoyama, M. Sugiura, K. Tomita, M. Imada, K. Taniguchi, T. Yoshino, K. Iwatsuki

Research output: Contribution to journalArticle

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Abstract

Hydroa vacciniforme (HV) is a rare photodermatosis that mainly affects children and manifests as vesiculopapular eruptions in sun-exposed areas without systemic symptoms. HV-like lymphoma (HVLL) is one of the Epstein-Barr virus (EBV)-associated lymphoproliferative disorders (LPD) of childhood. Its diagnosis is based on monoclonal T-cell proliferation; however, its degree of malignancy is controversial owing to its variable prognosis. Elderly-onset cases of these diseases are extremely rare, and the clinical features remain unknown. It has been shown that late onset is closely associated with a severe phenotype in EBV-associated LPD including atypical HV. Here we describe a case of elderly-onset atypical HV accompanied by T-cell monoclonality, but with a very indolent clinical course. Our patient indicates a possible case with elderly-onset atypical HV manifesting a favourable course, and that T-cell monoclonality and age of onset cannot always predict the disease severity, and highlights the difficulty of prognosis prediction in elderly-onset atypical HV. What's already known about this topic? Hydroa vacciniforme (HV)-like lymphoma is an Epstein-Barr virus (EBV)-associated disease characterized by T-cell monoclonality, with a rare elderly onset. Late onset is associated with severe phenotype in EBV associated lymphoproliferative disorder. What does this study add? A case of elderly-onset atypical HV with T-cell monoclonality who had a very indolent clinical course is presented. Such a case has never been reported before. Our case demonstrates the possibility of a patient with elderly-onset atypical HV who manifests a favourable course, and that the T-cell monoclonality and age of onset cannot always predict the disease.

Original languageEnglish
Pages (from-to)801-805
Number of pages5
JournalBritish Journal of Dermatology
Volume173
Issue number3
DOIs
Publication statusPublished - 2015 Sep 1
Externally publishedYes

Fingerprint

Hydroa Vacciniforme
Human Herpesvirus 4
T-Lymphocytes
Lymphoproliferative Disorders
Age of Onset
Lymphoma
Phenotype
Solar System
Virus Diseases
Rare Diseases

ASJC Scopus subject areas

  • Dermatology

Cite this

Nomura, H., Suzuki, H., Egami, S., Yokoyama, T., Sugiura, M., Tomita, K., ... Iwatsuki, K. (2015). A patient with elderly-onset atypical hydroa vacciniforme with an indolent clinical course. British Journal of Dermatology, 173(3), 801-805. https://doi.org/10.1111/bjd.13893

A patient with elderly-onset atypical hydroa vacciniforme with an indolent clinical course. / Nomura, Hisashi; Suzuki, H.; Egami, S.; Yokoyama, T.; Sugiura, M.; Tomita, K.; Imada, M.; Taniguchi, K.; Yoshino, T.; Iwatsuki, K.

In: British Journal of Dermatology, Vol. 173, No. 3, 01.09.2015, p. 801-805.

Research output: Contribution to journalArticle

Nomura, H, Suzuki, H, Egami, S, Yokoyama, T, Sugiura, M, Tomita, K, Imada, M, Taniguchi, K, Yoshino, T & Iwatsuki, K 2015, 'A patient with elderly-onset atypical hydroa vacciniforme with an indolent clinical course', British Journal of Dermatology, vol. 173, no. 3, pp. 801-805. https://doi.org/10.1111/bjd.13893
Nomura, Hisashi ; Suzuki, H. ; Egami, S. ; Yokoyama, T. ; Sugiura, M. ; Tomita, K. ; Imada, M. ; Taniguchi, K. ; Yoshino, T. ; Iwatsuki, K. / A patient with elderly-onset atypical hydroa vacciniforme with an indolent clinical course. In: British Journal of Dermatology. 2015 ; Vol. 173, No. 3. pp. 801-805.
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AU - Suzuki, H.

AU - Egami, S.

AU - Yokoyama, T.

AU - Sugiura, M.

AU - Tomita, K.

AU - Imada, M.

AU - Taniguchi, K.

AU - Yoshino, T.

AU - Iwatsuki, K.

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