A patient with genetic deletion of glutathione-S-transferase T1 and M1 who developed non-small-cell lung cancer and myelodysplastic syndromes

Yasumichi Arai, Nobuyoshi Hirose, Ken Yamamura, Maiko Nagai, Hong Jang, Yutaka Hattori, Yasuo Ikeda

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Glutathione S-transferase (GST) M1 polymorphism is a marker for susceptibility to smoking-related neoplasms, such as lung and bladder cancer. Recently, a genetic deletion of GSTT1, an isoenzyme of GST, has been reported to be associated with myelodysplastic syndromes (MDS). A 59-year-old man with a long-term smoking habit was treated successfully for non-small-cell lung cancer. Four years after the surgical removal of his lung cancer, he developed MDS and died. Using a polymerase chain reaction-based genotyping method, he was found to have a deletion of both the GSTM1 and GSTT1 genes. Screening for the deletion of the GSTM1 and GSTT1 genes may be useful for assessing individual genetic susceptibility to smoking-related lung cancer and MDS.

Original languageEnglish
Pages (from-to)424-427
Number of pages4
JournalAmerican Journal of the Medical Sciences
Volume318
Issue number6
DOIs
Publication statusPublished - 1999 Dec

Keywords

  • GSTT
  • Glutathione-S-Transferase M1 (GSTM1)
  • Lung cancer, Myelodysplastic syndromes (MDS), Smoking

ASJC Scopus subject areas

  • Medicine(all)

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