TY - JOUR
T1 - A patient with genetic deletion of glutathione-S-transferase T1 and M1 who developed non-small-cell lung cancer and myelodysplastic syndromes
AU - Arai, Yasumichi
AU - Hirose, Nobuyoshi
AU - Yamamura, Ken
AU - Nagai, Maiko
AU - Jang, Hong
AU - Hattori, Yutaka
AU - Ikeda, Yasuo
PY - 1999/12
Y1 - 1999/12
N2 - Glutathione S-transferase (GST) M1 polymorphism is a marker for susceptibility to smoking-related neoplasms, such as lung and bladder cancer. Recently, a genetic deletion of GSTT1, an isoenzyme of GST, has been reported to be associated with myelodysplastic syndromes (MDS). A 59-year-old man with a long-term smoking habit was treated successfully for non-small-cell lung cancer. Four years after the surgical removal of his lung cancer, he developed MDS and died. Using a polymerase chain reaction-based genotyping method, he was found to have a deletion of both the GSTM1 and GSTT1 genes. Screening for the deletion of the GSTM1 and GSTT1 genes may be useful for assessing individual genetic susceptibility to smoking-related lung cancer and MDS.
AB - Glutathione S-transferase (GST) M1 polymorphism is a marker for susceptibility to smoking-related neoplasms, such as lung and bladder cancer. Recently, a genetic deletion of GSTT1, an isoenzyme of GST, has been reported to be associated with myelodysplastic syndromes (MDS). A 59-year-old man with a long-term smoking habit was treated successfully for non-small-cell lung cancer. Four years after the surgical removal of his lung cancer, he developed MDS and died. Using a polymerase chain reaction-based genotyping method, he was found to have a deletion of both the GSTM1 and GSTT1 genes. Screening for the deletion of the GSTM1 and GSTT1 genes may be useful for assessing individual genetic susceptibility to smoking-related lung cancer and MDS.
KW - GSTT
KW - Glutathione-S-Transferase M1 (GSTM1)
KW - Lung cancer, Myelodysplastic syndromes (MDS), Smoking
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U2 - 10.1016/S0002-9629(15)40669-X
DO - 10.1016/S0002-9629(15)40669-X
M3 - Article
C2 - 10616169
AN - SCOPUS:0033499475
SN - 0002-9629
VL - 318
SP - 424
EP - 427
JO - American Journal of the Medical Sciences
JF - American Journal of the Medical Sciences
IS - 6
ER -
