A pharmacokinetic analysis program (multi) for microcomputer

Kiyoshi Yamaoka; Yusuke Tanigawara; Terumichi Nakagawa; Toyozo Uno

doi:10.1248/bpb1978.4.879

A pharmacokinetic analysis program (multi) for microcomputer

Kiyoshi Yamaoka, Yusuke Tanigawara, Terumichi Nakagawa, Toyozo Uno

Research output: Contribution to journal › Article › peer-review

2658 Citations (Scopus)

Abstract

A nonlinear least squares program (MULTI) for microcomputers was developed. The program is written in BASIC programming language. Four algorithms, (1) Gauss-Newton method, (2) damping Gauss-Newton method, (3) modified Marquardt method and (4) simplex method, can be used for nonlinear curve fitting in MULTI. Up to five pharmacokinetic equations, which are voluntarily defined by the user, are simultaneously fitted to observed time courses. The executions or MULTI are demonstrated for time courses of ampicillin and oxacillin in man.

Original language	English
Pages (from-to)	879-885
Number of pages	7
Journal	Journal of Pharmacobio-Dynamics
Volume	4
Issue number	11
DOIs	https://doi.org/10.1248/bpb1978.4.879
Publication status	Published - 1981
Externally published	Yes

Keywords

AIC
MULTI
SALS
curve fitting
least squares
microcomputer
pharmacokinetics

ASJC Scopus subject areas

Pharmacology

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10.1248/bpb1978.4.879

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AB - A nonlinear least squares program (MULTI) for microcomputers was developed. The program is written in BASIC programming language. Four algorithms, (1) Gauss-Newton method, (2) damping Gauss-Newton method, (3) modified Marquardt method and (4) simplex method, can be used for nonlinear curve fitting in MULTI. Up to five pharmacokinetic equations, which are voluntarily defined by the user, are simultaneously fitted to observed time courses. The executions or MULTI are demonstrated for time courses of ampicillin and oxacillin in man.

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KW - least squares

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KW - pharmacokinetics

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A pharmacokinetic analysis program (multi) for microcomputer

Abstract

Keywords

ASJC Scopus subject areas

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