A Phase III randomized trial of lobectomy versus limited resection for small-sized peripheral non-small cell lung cancer (JCOG0802/WJOG4607L)

Kenichi Nakamura, Hisashi Saji, Ryu Nakajima, Morihito Okada, Hisao Asamura, Taro Shibata, Shinichiro Nakamura, Hirohito Tada, Masahiro Tsuboi

Research output: Contribution to journalArticle

308 Citations (Scopus)

Abstract

A Phase III study was started in Japan to evaluate the non-inferiority in overall survival of segmentectomy compared with lobectomy in patients with small-sized (diameter ≤2 cm) peripheral non-small cell lung cancer, excluding radiologically determined non-invasive cancer. This study began in August 2009, and a total of 1100 patients will be accrued from 71 institutions within 3 years. The primary endpoint is overall survival. The secondary endpoints are post-operative respiratory function, relapse-free survival, proportion of local recurrence, adverse events, proportion of patients who complete segmentectomy, duration of hospitalization, duration of chest tube placement, operation time, blood loss and number of autosutures used. This study is one of the first intergroup studies in Japan between the Japan Clinical Oncology Group and the West Japan Oncology Group.

Original languageEnglish
Article numberhyp156
Pages (from-to)271-274
Number of pages4
JournalJapanese journal of clinical oncology
Volume40
Issue number3
DOIs
Publication statusPublished - 2009 Nov 22

Keywords

  • Clinical trial
  • Non-small cell lung carcinoma
  • Phase III
  • Pneumonectomy
  • Thoracic surgery

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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