A piezoresistive cellular traction force sensor

U. G. Jung; H. Takahashi; T. Kan; K. Matsumoto; I. Shimoyama

doi:10.1109/MEMSYS.2013.6474396

A piezoresistive cellular traction force sensor

U. G. Jung, H. Takahashi, T. Kan, K. Matsumoto, I. Shimoyama

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

5 Citations (Scopus)

Abstract

This paper presents a rigid piezoresistive sensor to measure cellular traction forces. The traction forces on a rigid substrate such as bone (10∼30 [GPa]) are still unknown. Our approach of the traction force measurement is not by an observation [1-4] but by a resistance change of the piezo-resistor due to the deformation of the rigid sensor (spring constant: 900 nN/μm). Because of its high sensitivity with sub-μN resolution, we were able to measure the traction forces on the rigid substrate. The stiffness of the proposed sensor was 10 times larger than that of previous works. We demonstrated that the traction forces generated by fibroblast were 0.7 μN when two cells adhered to the sensor.

Original language	English
Title of host publication	IEEE 26th International Conference on Micro Electro Mechanical Systems, MEMS 2013
Pages	927-930
Number of pages	4
DOIs	https://doi.org/10.1109/MEMSYS.2013.6474396
Publication status	Published - 2013 Apr 2
Externally published	Yes
Event	IEEE 26th International Conference on Micro Electro Mechanical Systems, MEMS 2013 - Taipei, Taiwan, Province of China Duration: 2013 Jan 20 → 2013 Jan 24

Publication series

Name	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN (Print)	1084-6999

Other

Other	IEEE 26th International Conference on Micro Electro Mechanical Systems, MEMS 2013
Country/Territory	Taiwan, Province of China
City	Taipei
Period	13/1/20 → 13/1/24

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Mechanical Engineering
Electrical and Electronic Engineering

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10.1109/MEMSYS.2013.6474396

Cite this

Jung, U. G., Takahashi, H., Kan, T., Matsumoto, K., & Shimoyama, I. (2013). A piezoresistive cellular traction force sensor. In IEEE 26th International Conference on Micro Electro Mechanical Systems, MEMS 2013 (pp. 927-930). [6474396] (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). https://doi.org/10.1109/MEMSYS.2013.6474396

A piezoresistive cellular traction force sensor. / Jung, U. G.; Takahashi, H.; Kan, T. et al.
IEEE 26th International Conference on Micro Electro Mechanical Systems, MEMS 2013. 2013. p. 927-930 6474396 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Jung, UG, Takahashi, H, Kan, T, Matsumoto, K & Shimoyama, I 2013, A piezoresistive cellular traction force sensor. in IEEE 26th International Conference on Micro Electro Mechanical Systems, MEMS 2013., 6474396, Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), pp. 927-930, IEEE 26th International Conference on Micro Electro Mechanical Systems, MEMS 2013, Taipei, Taiwan, Province of China, 13/1/20. https://doi.org/10.1109/MEMSYS.2013.6474396

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abstract = "This paper presents a rigid piezoresistive sensor to measure cellular traction forces. The traction forces on a rigid substrate such as bone (10∼30 [GPa]) are still unknown. Our approach of the traction force measurement is not by an observation [1-4] but by a resistance change of the piezo-resistor due to the deformation of the rigid sensor (spring constant: 900 nN/μm). Because of its high sensitivity with sub-μN resolution, we were able to measure the traction forces on the rigid substrate. The stiffness of the proposed sensor was 10 times larger than that of previous works. We demonstrated that the traction forces generated by fibroblast were 0.7 μN when two cells adhered to the sensor.",

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AB - This paper presents a rigid piezoresistive sensor to measure cellular traction forces. The traction forces on a rigid substrate such as bone (10∼30 [GPa]) are still unknown. Our approach of the traction force measurement is not by an observation [1-4] but by a resistance change of the piezo-resistor due to the deformation of the rigid sensor (spring constant: 900 nN/μm). Because of its high sensitivity with sub-μN resolution, we were able to measure the traction forces on the rigid substrate. The stiffness of the proposed sensor was 10 times larger than that of previous works. We demonstrated that the traction forces generated by fibroblast were 0.7 μN when two cells adhered to the sensor.

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A piezoresistive cellular traction force sensor

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