A Possible Mechanism of Immunotherapy for Patients With Recurrent Spontaneous Abortions

TOSHITAKA SUGI, TSUNEHISA MAKINO, TETSUO MARUYAMA, WOO KYOON KIM, RIHACHI IIZUKA

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

ABSTRACT: The mechanism of the beneficial effect of immunotherapy for human reproductive wastage remains to be elucidated. Induction of blocking antibodies such as anti‐HLA class II antibodies and anti‐idiotypic antibodies was investigated as the mechanism of specific immunosuppression in pregnancy. We reported the changes in the mixed lymphocyte reaction (MLR), T‐cell subsets, and generation of anti‐idiotypic antibodies after immunotherapy compared to before immunotherapy. MLR was significantly (P < 0.001) inhibited after the immunization. The mean inhibition rate was 50.2%, suggesting that MLR blocking antibodies were induced by immunotherapy. Binding of autoantibodies to alloactivated maternal lymphoblasts against the paternal lymphocytes was detected in postimmunization cases in two‐color flow‐cytometric experiments. This suggests that anti‐idiotypic antibodies were induced by the immunotherapy. The percentage of cytotoxic T‐cells was significantly decreased (P < 0.05) and the percentage of suppressor T‐cells was significantly increased (P < 0.01) after the immunotherapy, suggesting that a cell‐mediated immune response was induced by the immunotherapy. 1991 Munksgaard

Original languageEnglish
Pages (from-to)185-189
Number of pages5
JournalAmerican Journal of Reproductive Immunology
Volume25
Issue number4
DOIs
Publication statusPublished - 1991 May

Keywords

  • Immunotherapy
  • MLR
  • T‐cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynaecology

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