Abstract
The mechanism of the beneficial effect of immunotherapy for human reproductive wastage remains to be elucidated. Induction of blocking antibodies such as anti-HLA class II antibodies and anti-idiotypic antibodies was investigated as the mechanism of specific immunosuppression in pregnancy. We reported the changes in the mixed lymphocyte reaction (MLR), T-cell subsets, and generation of anti-idiotypic antibodies after immunotherapy compared to before immunotherapy. MLR was significantly (P < 0.001) inhibited after the immunization. The mean inhibition rate was 50.2%, suggesting that MLR blocking antibodies were induced by immunotherapy. Binding of autoantibodies to alloactivated maternal lymphoblasts against the paternal lymphocytes was detected in postimmunization cases in two-color flow-cytometric experiments. This suggests that anti-idiotypic antibodies were induced by the immunotherapy. The percentage of cytotoxic T-cells was significantly decreased (P < 0.05) and the percentage of suppressor T-cells was significantly increased (P < 0.01) after the immunotherapy, suggesting that a cell-mediated immune response was induced by the immunotherapy.
| Original language | English |
|---|---|
| Pages (from-to) | 185-189 |
| Number of pages | 5 |
| Journal | American Journal of Reproductive Immunology |
| Volume | 25 |
| Issue number | 4 |
| Publication status | Published - 1991 |
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Keywords
- immunotherapy
- MLR
- T-cells
ASJC Scopus subject areas
- Immunology
- Obstetrics and Gynaecology
Cite this
A possible mechanism of immunotherapy for patients with recurrent spontaneous abortions. / Sugi, T.; Makino, T.; Maruyama, Tetsuo; Kyoon Kim, W.; Iizuka, R.
In: American Journal of Reproductive Immunology, Vol. 25, No. 4, 1991, p. 185-189.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A possible mechanism of immunotherapy for patients with recurrent spontaneous abortions
AU - Sugi, T.
AU - Makino, T.
AU - Maruyama, Tetsuo
AU - Kyoon Kim, W.
AU - Iizuka, R.
PY - 1991
Y1 - 1991
N2 - The mechanism of the beneficial effect of immunotherapy for human reproductive wastage remains to be elucidated. Induction of blocking antibodies such as anti-HLA class II antibodies and anti-idiotypic antibodies was investigated as the mechanism of specific immunosuppression in pregnancy. We reported the changes in the mixed lymphocyte reaction (MLR), T-cell subsets, and generation of anti-idiotypic antibodies after immunotherapy compared to before immunotherapy. MLR was significantly (P < 0.001) inhibited after the immunization. The mean inhibition rate was 50.2%, suggesting that MLR blocking antibodies were induced by immunotherapy. Binding of autoantibodies to alloactivated maternal lymphoblasts against the paternal lymphocytes was detected in postimmunization cases in two-color flow-cytometric experiments. This suggests that anti-idiotypic antibodies were induced by the immunotherapy. The percentage of cytotoxic T-cells was significantly decreased (P < 0.05) and the percentage of suppressor T-cells was significantly increased (P < 0.01) after the immunotherapy, suggesting that a cell-mediated immune response was induced by the immunotherapy.
AB - The mechanism of the beneficial effect of immunotherapy for human reproductive wastage remains to be elucidated. Induction of blocking antibodies such as anti-HLA class II antibodies and anti-idiotypic antibodies was investigated as the mechanism of specific immunosuppression in pregnancy. We reported the changes in the mixed lymphocyte reaction (MLR), T-cell subsets, and generation of anti-idiotypic antibodies after immunotherapy compared to before immunotherapy. MLR was significantly (P < 0.001) inhibited after the immunization. The mean inhibition rate was 50.2%, suggesting that MLR blocking antibodies were induced by immunotherapy. Binding of autoantibodies to alloactivated maternal lymphoblasts against the paternal lymphocytes was detected in postimmunization cases in two-color flow-cytometric experiments. This suggests that anti-idiotypic antibodies were induced by the immunotherapy. The percentage of cytotoxic T-cells was significantly decreased (P < 0.05) and the percentage of suppressor T-cells was significantly increased (P < 0.01) after the immunotherapy, suggesting that a cell-mediated immune response was induced by the immunotherapy.
KW - immunotherapy
KW - MLR
KW - T-cells
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M3 - Article
C2 - 1838482
AN - SCOPUS:0025998420
VL - 25
SP - 185
EP - 189
JO - American Journal of Reproductive Immunology and Microbiology
JF - American Journal of Reproductive Immunology and Microbiology
SN - 8755-8920
IS - 4
ER -