A possible mechanism of immunotherapy for patients with recurrent spontaneous abortions

T. Sugi, T. Makino, Tetsuo Maruyama, W. Kyoon Kim, R. Iizuka

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The mechanism of the beneficial effect of immunotherapy for human reproductive wastage remains to be elucidated. Induction of blocking antibodies such as anti-HLA class II antibodies and anti-idiotypic antibodies was investigated as the mechanism of specific immunosuppression in pregnancy. We reported the changes in the mixed lymphocyte reaction (MLR), T-cell subsets, and generation of anti-idiotypic antibodies after immunotherapy compared to before immunotherapy. MLR was significantly (P < 0.001) inhibited after the immunization. The mean inhibition rate was 50.2%, suggesting that MLR blocking antibodies were induced by immunotherapy. Binding of autoantibodies to alloactivated maternal lymphoblasts against the paternal lymphocytes was detected in postimmunization cases in two-color flow-cytometric experiments. This suggests that anti-idiotypic antibodies were induced by the immunotherapy. The percentage of cytotoxic T-cells was significantly decreased (P < 0.05) and the percentage of suppressor T-cells was significantly increased (P < 0.01) after the immunotherapy, suggesting that a cell-mediated immune response was induced by the immunotherapy.

Original languageEnglish
Pages (from-to)185-189
Number of pages5
JournalAmerican Journal of Reproductive Immunology
Volume25
Issue number4
Publication statusPublished - 1991

Fingerprint

Habitual Abortion
Spontaneous Abortion
Immunotherapy
Mixed Lymphocyte Culture Test
Anti-Idiotypic Antibodies
Blocking Antibodies
T-Lymphocytes
Immunoglobulin Isotypes
T-Lymphocyte Subsets
Autoantibodies
Immunosuppression
Immunization
Color
Mothers
Lymphocytes
Pregnancy

Keywords

  • immunotherapy
  • MLR
  • T-cells

ASJC Scopus subject areas

  • Immunology
  • Obstetrics and Gynaecology

Cite this

A possible mechanism of immunotherapy for patients with recurrent spontaneous abortions. / Sugi, T.; Makino, T.; Maruyama, Tetsuo; Kyoon Kim, W.; Iizuka, R.

In: American Journal of Reproductive Immunology, Vol. 25, No. 4, 1991, p. 185-189.

Research output: Contribution to journalArticle

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