A potentially aborted neuroleptic malignant syndrome following seclusion against uncontrollable water intoxication.

Takefumi Suzuki, Hiroyuki Uchida, Koichiro Watanabe, Haruo Kashima

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Water intoxication in schizophrenia poses a great clinical challenge, and occasionally, behavioral restrictions are unavoidable. A patient with refractory schizophrenia comorbid with severe water intoxication had an apparent weight variation of ,7 kg/day to 65 kg. As he fell twice, when he had been treated with antipsychotic megadose therapy, he was secluded with restricted water access of 3 L/day. Two days later, consciousness level deteriorated significantly with autonomic instability; however, he was treated with intravenous hydration plus dantrolene and recovered completely on the following day. The sodium/chloride levels and serum osmolarity, which had been abnormally low, normalized abruptly. Only after seclusion was it found that his dry weight had been only 52 kg. The first description of such a case was indicative of a potentially aborted neuroleptic malignant syndrome. He is now treated with olanzapine, valproate, and lorazepam, with some success. Caution is required for secluding extreme cases of uncontrollable water intoxication.

Original languageEnglish
Pages (from-to)164-170
Number of pages7
JournalPsychopharmacology Bulletin
Volume41
Issue number1
Publication statusPublished - 2008
Externally publishedYes

Fingerprint

Water Intoxication
Neuroleptic Malignant Syndrome
olanzapine
Schizophrenia
Dantrolene
Lorazepam
Weights and Measures
Valproic Acid
Consciousness
Sodium Chloride
Osmolar Concentration
Antipsychotic Agents
Water
Serum
Therapeutics

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

A potentially aborted neuroleptic malignant syndrome following seclusion against uncontrollable water intoxication. / Suzuki, Takefumi; Uchida, Hiroyuki; Watanabe, Koichiro; Kashima, Haruo.

In: Psychopharmacology Bulletin, Vol. 41, No. 1, 2008, p. 164-170.

Research output: Contribution to journalArticle

@article{e4251452ddbb400c93994daf66aa7c9b,
title = "A potentially aborted neuroleptic malignant syndrome following seclusion against uncontrollable water intoxication.",
abstract = "Water intoxication in schizophrenia poses a great clinical challenge, and occasionally, behavioral restrictions are unavoidable. A patient with refractory schizophrenia comorbid with severe water intoxication had an apparent weight variation of ,7 kg/day to 65 kg. As he fell twice, when he had been treated with antipsychotic megadose therapy, he was secluded with restricted water access of 3 L/day. Two days later, consciousness level deteriorated significantly with autonomic instability; however, he was treated with intravenous hydration plus dantrolene and recovered completely on the following day. The sodium/chloride levels and serum osmolarity, which had been abnormally low, normalized abruptly. Only after seclusion was it found that his dry weight had been only 52 kg. The first description of such a case was indicative of a potentially aborted neuroleptic malignant syndrome. He is now treated with olanzapine, valproate, and lorazepam, with some success. Caution is required for secluding extreme cases of uncontrollable water intoxication.",
author = "Takefumi Suzuki and Hiroyuki Uchida and Koichiro Watanabe and Haruo Kashima",
year = "2008",
language = "English",
volume = "41",
pages = "164--170",
journal = "Psychopharmacology Bulletin",
issn = "0048-5764",
publisher = "MedWorks Media LLC",
number = "1",

}

TY - JOUR

T1 - A potentially aborted neuroleptic malignant syndrome following seclusion against uncontrollable water intoxication.

AU - Suzuki, Takefumi

AU - Uchida, Hiroyuki

AU - Watanabe, Koichiro

AU - Kashima, Haruo

PY - 2008

Y1 - 2008

N2 - Water intoxication in schizophrenia poses a great clinical challenge, and occasionally, behavioral restrictions are unavoidable. A patient with refractory schizophrenia comorbid with severe water intoxication had an apparent weight variation of ,7 kg/day to 65 kg. As he fell twice, when he had been treated with antipsychotic megadose therapy, he was secluded with restricted water access of 3 L/day. Two days later, consciousness level deteriorated significantly with autonomic instability; however, he was treated with intravenous hydration plus dantrolene and recovered completely on the following day. The sodium/chloride levels and serum osmolarity, which had been abnormally low, normalized abruptly. Only after seclusion was it found that his dry weight had been only 52 kg. The first description of such a case was indicative of a potentially aborted neuroleptic malignant syndrome. He is now treated with olanzapine, valproate, and lorazepam, with some success. Caution is required for secluding extreme cases of uncontrollable water intoxication.

AB - Water intoxication in schizophrenia poses a great clinical challenge, and occasionally, behavioral restrictions are unavoidable. A patient with refractory schizophrenia comorbid with severe water intoxication had an apparent weight variation of ,7 kg/day to 65 kg. As he fell twice, when he had been treated with antipsychotic megadose therapy, he was secluded with restricted water access of 3 L/day. Two days later, consciousness level deteriorated significantly with autonomic instability; however, he was treated with intravenous hydration plus dantrolene and recovered completely on the following day. The sodium/chloride levels and serum osmolarity, which had been abnormally low, normalized abruptly. Only after seclusion was it found that his dry weight had been only 52 kg. The first description of such a case was indicative of a potentially aborted neuroleptic malignant syndrome. He is now treated with olanzapine, valproate, and lorazepam, with some success. Caution is required for secluding extreme cases of uncontrollable water intoxication.

UR - http://www.scopus.com/inward/record.url?scp=84879789909&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879789909&partnerID=8YFLogxK

M3 - Article

VL - 41

SP - 164

EP - 170

JO - Psychopharmacology Bulletin

JF - Psychopharmacology Bulletin

SN - 0048-5764

IS - 1

ER -