A practical chemoenzymatic synthesis of a key intermediate of antifungal agents

Yoshihiko Yasohara, Kenji Miyamoto, Noriyuku Kizaki, Junzo Hasegawa, Takehisa Ohashi

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A novel synthesis of an azole antifungal building block, the optically active diol, is described. The key step involves an enantioselective hydrolysis of a prochiral diester by a lipase.

Original languageEnglish
Pages (from-to)3331-3333
Number of pages3
JournalTetrahedron Letters
Volume42
Issue number19
DOIs
Publication statusPublished - 2001 May 7
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'A practical chemoenzymatic synthesis of a key intermediate of antifungal agents'. Together they form a unique fingerprint.

  • Cite this