A practical chemoenzymatic synthesis of a key intermediate of antifungal agents

Yoshihiko Yasohara, Kenji Miyamoto, Noriyuku Kizaki, Junzo Hasegawa, Takehisa Ohashi

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A novel synthesis of an azole antifungal building block, the optically active diol, is described. The key step involves an enantioselective hydrolysis of a prochiral diester by a lipase.

Original languageEnglish
Pages (from-to)3331-3333
Number of pages3
JournalTetrahedron Letters
Volume42
Issue number19
DOIs
Publication statusPublished - 2001 May 7
Externally publishedYes

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Azoles
Antifungal Agents
Lipase
Hydrolysis

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

A practical chemoenzymatic synthesis of a key intermediate of antifungal agents. / Yasohara, Yoshihiko; Miyamoto, Kenji; Kizaki, Noriyuku; Hasegawa, Junzo; Ohashi, Takehisa.

In: Tetrahedron Letters, Vol. 42, No. 19, 07.05.2001, p. 3331-3333.

Research output: Contribution to journalArticle

Yasohara, Yoshihiko ; Miyamoto, Kenji ; Kizaki, Noriyuku ; Hasegawa, Junzo ; Ohashi, Takehisa. / A practical chemoenzymatic synthesis of a key intermediate of antifungal agents. In: Tetrahedron Letters. 2001 ; Vol. 42, No. 19. pp. 3331-3333.
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