A randomized controlled trial comparing laparoscopic surgery with open surgery in palliative resection of primary tumor in incurable stage IV colorectal cancer: Japan clinical oncology group study JCOG 1107 (ENCORE trial)

Masafumi Inomata, Tomonori Akagi, Hiroshi Katayama, Aya Kimura, Junki Mizusawa, Tsuyoshi Etoh, Shigeki Yamaguchi, Masaaki Ito, Yusuke Kinugasa, Yoshihisa Saida, Hirotoshi Hasegawa, Mitsuyoshi Ota, Yukihide Kanemitsu, Yasuhiro Shimada, Seigo Kitano

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2 Citations (Scopus)

Abstract

A randomized controlled trial was started in Japan to evaluate the non-inferiority of overall survival of laparoscopic surgery to open surgery for palliative resection of primary tumor in incurable Stage IV colorectal cancer. Symptomatic, Stage IV colorectal cancer patients with non-curable metastasis are pre-operatively randomized to either open or laparoscopic colorectal resection. Surgeons in 56 specialized institutions will recruit 450 patients. The primary endpoint is overall survival. Secondary endpoints are progression-free survival, the proportion of conversion from laparoscopic surgery to open surgery, the proportion of patients who fulfill the criteria of starting chemotherapy by 6 weeks after operation, intraoperative and post-operative complications, adverse events during chemotherapy and serious adverse events.

Original languageEnglish
Pages (from-to)1123-1126
Number of pages4
JournalJapanese Journal of Clinical Oncology
Volume44
Issue number11
DOIs
Publication statusPublished - 2014

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Keywords

  • Aparoscopic surgery
  • Colorectal cancer
  • Palliative resection
  • Randomized controlled trial

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Inomata, M., Akagi, T., Katayama, H., Kimura, A., Mizusawa, J., Etoh, T., Yamaguchi, S., Ito, M., Kinugasa, Y., Saida, Y., Hasegawa, H., Ota, M., Kanemitsu, Y., Shimada, Y., & Kitano, S. (2014). A randomized controlled trial comparing laparoscopic surgery with open surgery in palliative resection of primary tumor in incurable stage IV colorectal cancer: Japan clinical oncology group study JCOG 1107 (ENCORE trial). Japanese Journal of Clinical Oncology, 44(11), 1123-1126. https://doi.org/10.1093/jjco/hyu115