A randomized controlled trial comparing laparoscopic surgery with open surgery in palliative resection of primary tumor in incurable stage IV colorectal cancer: Japan clinical oncology group study JCOG 1107 (ENCORE trial)

For the Colorectal Cancer Study Group (CCSG) of Japan Clinical Oncology Group

Research output: Contribution to journalComment/debate

2 Citations (Scopus)

Abstract

A randomized controlled trial was started in Japan to evaluate the non-inferiority of overall survival of laparoscopic surgery to open surgery for palliative resection of primary tumor in incurable Stage IV colorectal cancer. Symptomatic, Stage IV colorectal cancer patients with non-curable metastasis are pre-operatively randomized to either open or laparoscopic colorectal resection. Surgeons in 56 specialized institutions will recruit 450 patients. The primary endpoint is overall survival. Secondary endpoints are progression-free survival, the proportion of conversion from laparoscopic surgery to open surgery, the proportion of patients who fulfill the criteria of starting chemotherapy by 6 weeks after operation, intraoperative and post-operative complications, adverse events during chemotherapy and serious adverse events.

Original languageEnglish
Pages (from-to)1123-1126
Number of pages4
JournalJapanese journal of clinical oncology
Volume44
Issue number11
DOIs
Publication statusPublished - 2014

Keywords

  • Aparoscopic surgery
  • Colorectal cancer
  • Palliative resection
  • Randomized controlled trial

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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