A rare case of fungal endocarditis caused by Candida glabrata after completion of antibiotic therapy for Streptococcus endocarditis

Toshimitsu Tsugu, Mitsushige Murata, Shiro Iwanaga, Yohei Kitamura, Soushin Inoue, Keiichi Fukuda

Research output: Contribution to journalArticlepeer-review

Abstract

We present the rare case of a 76-year-old female with infective endocarditis (IE) caused by Candida glabrata. Immediately before developing the present infection, she developed IE with vegetation on the mitral annular calcification, which was caused by Streptococcus mitis and successfully treated with penicillin-G and gentamicin. However, her fever recurred, and she developed disseminated intravascular coagulation. Blood culture revealed C. glabrata, and echocardiography revealed new vegetation on the mitral valve. After 4 weeks of treatment with micafungin, prosthetic valve replacement was performed, followed by additional administration of micafungin for 4 weeks (total of 8 weeks). No relapse at 9 months after surgery has been observed. C. glabrata endocarditis is extremely rare and difficult to manage. Our case and review of past reported cases suggest that early diagnosis and initiation of treatment contribute to good prognosis of C. glabrata endocarditis.

Original languageEnglish
Pages (from-to)243-246
Number of pages4
JournalJournal of Medical Ultrasonics
Volume42
Issue number2
DOIs
Publication statusPublished - 2015 Apr 1

Keywords

  • Candida glabrata
  • Echocardiography
  • Fungal endocarditis
  • Micafungin
  • Mitral valve replacement

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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