A recent trial of chemo-radiation with S-1 against gastric cancer

Yoshirou Saikawa, Tsuyoshi Kiyota, Rieko Nakamura, Norihito Wada, Masashi Yoshida, Tetsuro Kubota, Koichiro Kumai, Naoyuki Shigematsu, Atsushi Kubo, Masaki Kitajima

Research output: Contribution to journalReview article

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Abstract

A recent development of novel anticancer agents like S-1, CPT-11 or taxanes has improved a therapeutic outcome for advanced gastric cancer, while conventional anticancer agents showed less anticancer effect against gastric cancer. The present main drug in Japan is S-1, which is easily used for outpatient with a high efficacy rate and low toxicity, also shows better effect in combination with other anticancer drugs than S-1 alone. In the present article, we demonstrated significant meaning of additional radiation therapy with anticancer drugs like S-1. With novel anticancer drugs like S-1, we will expose a clinical advantage and appropriateness for chemo-radiation therapy against gastric cancer discussed in the present references according to chemo-radiation therapy. Although chemo-radiation therapy has been recognized as one of the standard therapies for gastric cancer in Western countries, radiation therapy was selected in Japan for palliation therapy of recurrent disease or a terminal cancer to improve patients' QOL. On the other hand, we demonstrated in our trial of chemo-radiation therapy with S-1/low-dose CDDP/radiation (TSLDR), which was applied to initial treatment against highly advanced Stage IV gastric cancer and revealed the usefulness of the regimen in anticancer effect and toxicity. In addition, chemo-radiation therapy including novel anticancer agents like S-1 will be discussed based on various kinds of view points, expecting a better clinical outcome of multimodal therapies against advanced gastric cancer.

Original languageEnglish
Pages (from-to)99-105
Number of pages7
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume33 Suppl 1
Publication statusPublished - 2006 Jun

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Saikawa, Y., Kiyota, T., Nakamura, R., Wada, N., Yoshida, M., Kubota, T., Kumai, K., Shigematsu, N., Kubo, A., & Kitajima, M. (2006). A recent trial of chemo-radiation with S-1 against gastric cancer. Gan to kagaku ryoho. Cancer & chemotherapy, 33 Suppl 1, 99-105.