A Replication Study for the Association of rs11190870 with Curve Severity in Adolescent Idiopathic Scoliosis in Japanese

Yohei Takahashi, Ikuyo Kou, Yoji Ogura, Atsushi Miyake, Kazuki Takeda, Masahiro Nakajima, Shohei Minami, Noriaki Kawakami, Koki Uno, Manabu Ito, Ikuho Yonezawa, Takashi Kaito, Haruhisa Yanagida, Kei Watanabe, Hiroshi Taneichi, Katsumi Harimaya, Yuki Taniguchi, Toshiaki Kotani, Taichi Tsuji, Teppei Suzuki & 18 others Hideki Sudo, Nobuyuki Fujita, Mitsuru Yagi, Kazuhiro Chiba, Katsuki Kono, Tsuyoshi Sakuma, Tsutomu Akazawa, Kotaro Nishida, Kenichiro Kakutani, Hideki Shigematsu, Takahiro Iida, Satoru Demura, Naobumi Hosogane, Eijiro Okada, Masaya Nakamura, Morio Matsumoto, Koota Watanabe, Shiro Ikegawa

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Study Design. Case-only study. Objective. The aim of this study was to confirm the association of rs11190870 with adolescent idiopathic scoliosis (AIS) severity in Japanese patients with AIS. Summary of Background Data. Although the association of rs11190870 with AIS susceptibility is replicated in multiple ethnics, the association of rs11190870 with curve severity is controversial. Since the previous studies are of small, we performed a replication study using far larger number of patients than previous studies. Methods. A total of 1860 Japanese patients with AIS who had reached skeletal maturity or undergone surgical fusion were included in the study. We evaluated the association between rs11190870 and AIS progression for the entire group, and then for patients grouped according to a severe curve (a Cobb angle of ≥40°) or mild curve (a Cobb angle <30°). Because braces could affect the results of the present study, patients in the mild-curve group were divided according to whether or not they had worn a brace. We then evaluated associations between rs11190870 genotype and curve severity in these groups. Results. The mean Cobb angles were 54.8° ± 12.1° in the severe-curve group and 24.4° ± 4.0° in the mild-curve group. The difference in rs11190870 risk-allele frequency between the severe- and mild-curve groups was evaluated. No significant differences were observed. We then examined the association of rs11190870 risk-allele frequency between patients in the mild- and severe-curve groups using the χ 2 test for three models, and found a marginal association between rs11190870 and curve severity in the dominant model (P = 0.035, odds ratio = 1.51). Conclusion. We found no association between rs11190870 and curve severity using the criteria of previous study. However, we found a marginal association between rs11190870 and curve severity. Large-scale replication studies that consider skeletal maturity and brace history, including replication studies in other ethnic groups, would be helpful for clarifying the association. Level of Evidence: 4.

Original languageEnglish
Pages (from-to)688-692
Number of pages5
JournalSpine
Volume43
Issue number10
DOIs
Publication statusPublished - 2018 May 15

Fingerprint

Scoliosis
Braces
Gene Frequency
Ethnic Groups
History
Odds Ratio
Genotype

Keywords

  • adolescent idiopathic scoliosis
  • curve severity
  • genome-wide association study
  • Japanese
  • replication study
  • Risser sign
  • rs11190870
  • single nucleotide polymorphism
  • skeletal maturity

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Clinical Neurology

Cite this

Takahashi, Y., Kou, I., Ogura, Y., Miyake, A., Takeda, K., Nakajima, M., ... Ikegawa, S. (2018). A Replication Study for the Association of rs11190870 with Curve Severity in Adolescent Idiopathic Scoliosis in Japanese. Spine, 43(10), 688-692. https://doi.org/10.1097/BRS.0000000000002413

A Replication Study for the Association of rs11190870 with Curve Severity in Adolescent Idiopathic Scoliosis in Japanese. / Takahashi, Yohei; Kou, Ikuyo; Ogura, Yoji; Miyake, Atsushi; Takeda, Kazuki; Nakajima, Masahiro; Minami, Shohei; Kawakami, Noriaki; Uno, Koki; Ito, Manabu; Yonezawa, Ikuho; Kaito, Takashi; Yanagida, Haruhisa; Watanabe, Kei; Taneichi, Hiroshi; Harimaya, Katsumi; Taniguchi, Yuki; Kotani, Toshiaki; Tsuji, Taichi; Suzuki, Teppei; Sudo, Hideki; Fujita, Nobuyuki; Yagi, Mitsuru; Chiba, Kazuhiro; Kono, Katsuki; Sakuma, Tsuyoshi; Akazawa, Tsutomu; Nishida, Kotaro; Kakutani, Kenichiro; Shigematsu, Hideki; Iida, Takahiro; Demura, Satoru; Hosogane, Naobumi; Okada, Eijiro; Nakamura, Masaya; Matsumoto, Morio; Watanabe, Koota; Ikegawa, Shiro.

In: Spine, Vol. 43, No. 10, 15.05.2018, p. 688-692.

Research output: Contribution to journalArticle

Takahashi, Y, Kou, I, Ogura, Y, Miyake, A, Takeda, K, Nakajima, M, Minami, S, Kawakami, N, Uno, K, Ito, M, Yonezawa, I, Kaito, T, Yanagida, H, Watanabe, K, Taneichi, H, Harimaya, K, Taniguchi, Y, Kotani, T, Tsuji, T, Suzuki, T, Sudo, H, Fujita, N, Yagi, M, Chiba, K, Kono, K, Sakuma, T, Akazawa, T, Nishida, K, Kakutani, K, Shigematsu, H, Iida, T, Demura, S, Hosogane, N, Okada, E, Nakamura, M, Matsumoto, M, Watanabe, K & Ikegawa, S 2018, 'A Replication Study for the Association of rs11190870 with Curve Severity in Adolescent Idiopathic Scoliosis in Japanese', Spine, vol. 43, no. 10, pp. 688-692. https://doi.org/10.1097/BRS.0000000000002413
Takahashi, Yohei ; Kou, Ikuyo ; Ogura, Yoji ; Miyake, Atsushi ; Takeda, Kazuki ; Nakajima, Masahiro ; Minami, Shohei ; Kawakami, Noriaki ; Uno, Koki ; Ito, Manabu ; Yonezawa, Ikuho ; Kaito, Takashi ; Yanagida, Haruhisa ; Watanabe, Kei ; Taneichi, Hiroshi ; Harimaya, Katsumi ; Taniguchi, Yuki ; Kotani, Toshiaki ; Tsuji, Taichi ; Suzuki, Teppei ; Sudo, Hideki ; Fujita, Nobuyuki ; Yagi, Mitsuru ; Chiba, Kazuhiro ; Kono, Katsuki ; Sakuma, Tsuyoshi ; Akazawa, Tsutomu ; Nishida, Kotaro ; Kakutani, Kenichiro ; Shigematsu, Hideki ; Iida, Takahiro ; Demura, Satoru ; Hosogane, Naobumi ; Okada, Eijiro ; Nakamura, Masaya ; Matsumoto, Morio ; Watanabe, Koota ; Ikegawa, Shiro. / A Replication Study for the Association of rs11190870 with Curve Severity in Adolescent Idiopathic Scoliosis in Japanese. In: Spine. 2018 ; Vol. 43, No. 10. pp. 688-692.
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TY - JOUR

T1 - A Replication Study for the Association of rs11190870 with Curve Severity in Adolescent Idiopathic Scoliosis in Japanese

AU - Takahashi, Yohei

AU - Kou, Ikuyo

AU - Ogura, Yoji

AU - Miyake, Atsushi

AU - Takeda, Kazuki

AU - Nakajima, Masahiro

AU - Minami, Shohei

AU - Kawakami, Noriaki

AU - Uno, Koki

AU - Ito, Manabu

AU - Yonezawa, Ikuho

AU - Kaito, Takashi

AU - Yanagida, Haruhisa

AU - Watanabe, Kei

AU - Taneichi, Hiroshi

AU - Harimaya, Katsumi

AU - Taniguchi, Yuki

AU - Kotani, Toshiaki

AU - Tsuji, Taichi

AU - Suzuki, Teppei

AU - Sudo, Hideki

AU - Fujita, Nobuyuki

AU - Yagi, Mitsuru

AU - Chiba, Kazuhiro

AU - Kono, Katsuki

AU - Sakuma, Tsuyoshi

AU - Akazawa, Tsutomu

AU - Nishida, Kotaro

AU - Kakutani, Kenichiro

AU - Shigematsu, Hideki

AU - Iida, Takahiro

AU - Demura, Satoru

AU - Hosogane, Naobumi

AU - Okada, Eijiro

AU - Nakamura, Masaya

AU - Matsumoto, Morio

AU - Watanabe, Koota

AU - Ikegawa, Shiro

PY - 2018/5/15

Y1 - 2018/5/15

N2 - Study Design. Case-only study. Objective. The aim of this study was to confirm the association of rs11190870 with adolescent idiopathic scoliosis (AIS) severity in Japanese patients with AIS. Summary of Background Data. Although the association of rs11190870 with AIS susceptibility is replicated in multiple ethnics, the association of rs11190870 with curve severity is controversial. Since the previous studies are of small, we performed a replication study using far larger number of patients than previous studies. Methods. A total of 1860 Japanese patients with AIS who had reached skeletal maturity or undergone surgical fusion were included in the study. We evaluated the association between rs11190870 and AIS progression for the entire group, and then for patients grouped according to a severe curve (a Cobb angle of ≥40°) or mild curve (a Cobb angle <30°). Because braces could affect the results of the present study, patients in the mild-curve group were divided according to whether or not they had worn a brace. We then evaluated associations between rs11190870 genotype and curve severity in these groups. Results. The mean Cobb angles were 54.8° ± 12.1° in the severe-curve group and 24.4° ± 4.0° in the mild-curve group. The difference in rs11190870 risk-allele frequency between the severe- and mild-curve groups was evaluated. No significant differences were observed. We then examined the association of rs11190870 risk-allele frequency between patients in the mild- and severe-curve groups using the χ 2 test for three models, and found a marginal association between rs11190870 and curve severity in the dominant model (P = 0.035, odds ratio = 1.51). Conclusion. We found no association between rs11190870 and curve severity using the criteria of previous study. However, we found a marginal association between rs11190870 and curve severity. Large-scale replication studies that consider skeletal maturity and brace history, including replication studies in other ethnic groups, would be helpful for clarifying the association. Level of Evidence: 4.

AB - Study Design. Case-only study. Objective. The aim of this study was to confirm the association of rs11190870 with adolescent idiopathic scoliosis (AIS) severity in Japanese patients with AIS. Summary of Background Data. Although the association of rs11190870 with AIS susceptibility is replicated in multiple ethnics, the association of rs11190870 with curve severity is controversial. Since the previous studies are of small, we performed a replication study using far larger number of patients than previous studies. Methods. A total of 1860 Japanese patients with AIS who had reached skeletal maturity or undergone surgical fusion were included in the study. We evaluated the association between rs11190870 and AIS progression for the entire group, and then for patients grouped according to a severe curve (a Cobb angle of ≥40°) or mild curve (a Cobb angle <30°). Because braces could affect the results of the present study, patients in the mild-curve group were divided according to whether or not they had worn a brace. We then evaluated associations between rs11190870 genotype and curve severity in these groups. Results. The mean Cobb angles were 54.8° ± 12.1° in the severe-curve group and 24.4° ± 4.0° in the mild-curve group. The difference in rs11190870 risk-allele frequency between the severe- and mild-curve groups was evaluated. No significant differences were observed. We then examined the association of rs11190870 risk-allele frequency between patients in the mild- and severe-curve groups using the χ 2 test for three models, and found a marginal association between rs11190870 and curve severity in the dominant model (P = 0.035, odds ratio = 1.51). Conclusion. We found no association between rs11190870 and curve severity using the criteria of previous study. However, we found a marginal association between rs11190870 and curve severity. Large-scale replication studies that consider skeletal maturity and brace history, including replication studies in other ethnic groups, would be helpful for clarifying the association. Level of Evidence: 4.

KW - adolescent idiopathic scoliosis

KW - curve severity

KW - genome-wide association study

KW - Japanese

KW - replication study

KW - Risser sign

KW - rs11190870

KW - single nucleotide polymorphism

KW - skeletal maturity

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