Abstract
Through functional expression screening, we identified a gene, designated Humanin (HN) cDNA, which encodes a short polypeptide and abolishes death of neuronal cells caused by multiple different types of familial Alzheimer's disease genes and by Aβ amyloid, without effect on death by Q79 or superoxide dismutase-1 mutants. Transfected HN cDNA was transcribed to the corresponding polypeptide and then was secreted into the cultured medium. The rescue action clearly depended on the primary structure of HN. This polypeptide would serve as a molecular clue for the development of new therapeutics for Alzheimer's disease targeting neuroprotection.
| Original language | English |
|---|---|
| Pages (from-to) | 6336-6341 |
| Number of pages | 6 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 98 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2001 May 22 |
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ASJC Scopus subject areas
- Genetics
- General
Cite this
A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ. / Hashimoto, Yuichi; Niikura, Takako; Tajima, Hirohisa; Yasukawa, Takashi; Sudo, Haruka; Ito, Yuko; Kita, Yoshiko; Kawasumi, Masaoki; Koyama, Keisuke; Doyu, Manabu; Sobue, Gen; Koide, Takashi; Tsuji, Shoji; Lang, Jochen; Kurokawa, Kiyoshi; Nishimoto, Ikuo.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, No. 11, 22.05.2001, p. 6336-6341.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ
AU - Hashimoto, Yuichi
AU - Niikura, Takako
AU - Tajima, Hirohisa
AU - Yasukawa, Takashi
AU - Sudo, Haruka
AU - Ito, Yuko
AU - Kita, Yoshiko
AU - Kawasumi, Masaoki
AU - Koyama, Keisuke
AU - Doyu, Manabu
AU - Sobue, Gen
AU - Koide, Takashi
AU - Tsuji, Shoji
AU - Lang, Jochen
AU - Kurokawa, Kiyoshi
AU - Nishimoto, Ikuo
PY - 2001/5/22
Y1 - 2001/5/22
N2 - Through functional expression screening, we identified a gene, designated Humanin (HN) cDNA, which encodes a short polypeptide and abolishes death of neuronal cells caused by multiple different types of familial Alzheimer's disease genes and by Aβ amyloid, without effect on death by Q79 or superoxide dismutase-1 mutants. Transfected HN cDNA was transcribed to the corresponding polypeptide and then was secreted into the cultured medium. The rescue action clearly depended on the primary structure of HN. This polypeptide would serve as a molecular clue for the development of new therapeutics for Alzheimer's disease targeting neuroprotection.
AB - Through functional expression screening, we identified a gene, designated Humanin (HN) cDNA, which encodes a short polypeptide and abolishes death of neuronal cells caused by multiple different types of familial Alzheimer's disease genes and by Aβ amyloid, without effect on death by Q79 or superoxide dismutase-1 mutants. Transfected HN cDNA was transcribed to the corresponding polypeptide and then was secreted into the cultured medium. The rescue action clearly depended on the primary structure of HN. This polypeptide would serve as a molecular clue for the development of new therapeutics for Alzheimer's disease targeting neuroprotection.
UR - http://www.scopus.com/inward/record.url?scp=4243333514&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4243333514&partnerID=8YFLogxK
U2 - 10.1073/pnas.101133498
DO - 10.1073/pnas.101133498
M3 - Article
C2 - 11371646
AN - SCOPUS:4243333514
VL - 98
SP - 6336
EP - 6341
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 11
ER -