A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ

Yuichi Hashimoto, Takako Niikura, Hirohisa Tajima, Takashi Yasukawa, Haruka Sudo, Yuko Ito, Yoshiko Kita, Masaoki Kawasumi, Keisuke Koyama, Manabu Doyu, Gen Sobue, Takashi Koide, Shoji Tsuji, Jochen Lang, Kiyoshi Kurokawa, Ikuo Nishimoto

Research output: Contribution to journalArticle

352 Citations (Scopus)

Abstract

Through functional expression screening, we identified a gene, designated Humanin (HN) cDNA, which encodes a short polypeptide and abolishes death of neuronal cells caused by multiple different types of familial Alzheimer's disease genes and by Aβ amyloid, without effect on death by Q79 or superoxide dismutase-1 mutants. Transfected HN cDNA was transcribed to the corresponding polypeptide and then was secreted into the cultured medium. The rescue action clearly depended on the primary structure of HN. This polypeptide would serve as a molecular clue for the development of new therapeutics for Alzheimer's disease targeting neuroprotection.

Original languageEnglish
Pages (from-to)6336-6341
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume98
Issue number11
DOIs
Publication statusPublished - 2001 May 22

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Alzheimer Disease
Cell Death
Peptides
Complementary DNA
Genes
Amyloid
humanin
Therapeutics
Superoxide Dismutase-1
Neuroprotection

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ. / Hashimoto, Yuichi; Niikura, Takako; Tajima, Hirohisa; Yasukawa, Takashi; Sudo, Haruka; Ito, Yuko; Kita, Yoshiko; Kawasumi, Masaoki; Koyama, Keisuke; Doyu, Manabu; Sobue, Gen; Koide, Takashi; Tsuji, Shoji; Lang, Jochen; Kurokawa, Kiyoshi; Nishimoto, Ikuo.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, No. 11, 22.05.2001, p. 6336-6341.

Research output: Contribution to journalArticle

Hashimoto, Y, Niikura, T, Tajima, H, Yasukawa, T, Sudo, H, Ito, Y, Kita, Y, Kawasumi, M, Koyama, K, Doyu, M, Sobue, G, Koide, T, Tsuji, S, Lang, J, Kurokawa, K & Nishimoto, I 2001, 'A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ', Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 11, pp. 6336-6341. https://doi.org/10.1073/pnas.101133498
Hashimoto, Yuichi ; Niikura, Takako ; Tajima, Hirohisa ; Yasukawa, Takashi ; Sudo, Haruka ; Ito, Yuko ; Kita, Yoshiko ; Kawasumi, Masaoki ; Koyama, Keisuke ; Doyu, Manabu ; Sobue, Gen ; Koide, Takashi ; Tsuji, Shoji ; Lang, Jochen ; Kurokawa, Kiyoshi ; Nishimoto, Ikuo. / A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ. In: Proceedings of the National Academy of Sciences of the United States of America. 2001 ; Vol. 98, No. 11. pp. 6336-6341.
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