A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ

Yuichi Hashimoto; Takako Niikura; Hirohisa Tajima; Takashi Yasukawa; Haruka Sudo; Yuko Ito; Yoshiko Kita; Masaoki Kawasumi; Keisuke Kouyama; Manabu Doyu; Gen Sobue; Takashi Koide; Shoji Tsuji; Jochen Lang; Kiyoshi Kurokawa; Ikuo Nishimoto

doi:10.1073/pnas.101133498

A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ

Yuichi Hashimoto, Takako Niikura, Hirohisa Tajima, Takashi Yasukawa, Haruka Sudo, Yuko Ito, Yoshiko Kita, Masaoki Kawasumi, Keisuke Kouyama, Manabu Doyu, Gen Sobue, Takashi Koide, Shoji Tsuji, Jochen Lang, Kiyoshi Kurokawa, Ikuo Nishimoto

Clinical Research Aministration Center

Research output: Contribution to journal › Article

381 Citations (Scopus)

Abstract

Through functional expression screening, we identified a gene, designated Humanin (HN) cDNA, which encodes a short polypeptide and abolishes death of neuronal cells caused by multiple different types of familial Alzheimer's disease genes and by Aβ amyloid, without effect on death by Q79 or superoxide dismutase-1 mutants. Transfected HN cDNA was transcribed to the corresponding polypeptide and then was secreted into the cultured medium. The rescue action clearly depended on the primary structure of HN. This polypeptide would serve as a molecular clue for the development of new therapeutics for Alzheimer's disease targeting neuroprotection.

Original language	English
Pages (from-to)	6336-6341
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	98
Issue number	11
DOIs	https://doi.org/10.1073/pnas.101133498
Publication status	Published - 2001 May 22

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Hashimoto, Y., Niikura, T., Tajima, H., Yasukawa, T., Sudo, H., Ito, Y., Kita, Y., Kawasumi, M., Kouyama, K., Doyu, M., Sobue, G., Koide, T., Tsuji, S., Lang, J., Kurokawa, K., & Nishimoto, I. (2001). A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ. Proceedings of the National Academy of Sciences of the United States of America, 98(11), 6336-6341. https://doi.org/10.1073/pnas.101133498

A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ. / Hashimoto, Yuichi; Niikura, Takako; Tajima, Hirohisa; Yasukawa, Takashi; Sudo, Haruka; Ito, Yuko; Kita, Yoshiko; Kawasumi, Masaoki; Kouyama, Keisuke; Doyu, Manabu; Sobue, Gen; Koide, Takashi; Tsuji, Shoji; Lang, Jochen; Kurokawa, Kiyoshi; Nishimoto, Ikuo.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, No. 11, 22.05.2001, p. 6336-6341.

Research output: Contribution to journal › Article

Hashimoto, Y, Niikura, T, Tajima, H, Yasukawa, T, Sudo, H, Ito, Y, Kita, Y, Kawasumi, M, Kouyama, K, Doyu, M, Sobue, G, Koide, T, Tsuji, S, Lang, J, Kurokawa, K & Nishimoto, I 2001, 'A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ', Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 11, pp. 6336-6341. https://doi.org/10.1073/pnas.101133498

Hashimoto, Yuichi ; Niikura, Takako ; Tajima, Hirohisa ; Yasukawa, Takashi ; Sudo, Haruka ; Ito, Yuko ; Kita, Yoshiko ; Kawasumi, Masaoki ; Kouyama, Keisuke ; Doyu, Manabu ; Sobue, Gen ; Koide, Takashi ; Tsuji, Shoji ; Lang, Jochen ; Kurokawa, Kiyoshi ; Nishimoto, Ikuo. / A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ. In: Proceedings of the National Academy of Sciences of the United States of America. 2001 ; Vol. 98, No. 11. pp. 6336-6341.

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