A reticuloendothelial system-activating glycan from the roots of Astragalus membranaceus

Masashi Tomoda, Noriko Shimizu, Naoko Ohara, Ryoko Gonda, Sachiko Ishii, Hiroko Otsuki

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

From the hot water extract of the roots of Astragalus membranaceus, a glycan, designated as AMem-P, has been isolated by treatment with cetyltrimethylammonium bromide followed by column chromatography on Toyopearl HW60F and Con A-Sepharose columns. Chemical and spectroscopic studies established that the glycan possesses mainly α-1,2-linked l-rhamno-α-1,4-linked d-galacturonan structure. Terminal and α-1,5-linked l-arabinofuranose, terminal, β-1,3-, β-1,4- and β-1,6-linked and 3,6-branched d-galactose, and 2,4-branched l-rhamnose residues were also identified as the component sugar units. The glycan showed remarkable reticuloendothelial system-potentiating activity in the carbon clearance test.

Original languageEnglish
Pages (from-to)63-66
Number of pages4
JournalPhytochemistry
Volume31
Issue number1
DOIs
Publication statusPublished - 1991

Fingerprint

Astragalus membranaceus
reticuloendothelial system
Mononuclear Phagocyte System
Polysaccharides
polysaccharides
Rhamnose
Column chromatography
rhamnose
Galactose
Sugars
galactose
agarose
Chromatography
chromatography
Carbon
sugars
Water
carbon
extracts
water

Keywords

  • Astragalus membranaceus
  • Leguminosae
  • phagocytic activity.
  • polysaccharide
  • root
  • structural analysis

ASJC Scopus subject areas

  • Plant Science
  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery

Cite this

A reticuloendothelial system-activating glycan from the roots of Astragalus membranaceus. / Tomoda, Masashi; Shimizu, Noriko; Ohara, Naoko; Gonda, Ryoko; Ishii, Sachiko; Otsuki, Hiroko.

In: Phytochemistry, Vol. 31, No. 1, 1991, p. 63-66.

Research output: Contribution to journalArticle

Tomoda, Masashi ; Shimizu, Noriko ; Ohara, Naoko ; Gonda, Ryoko ; Ishii, Sachiko ; Otsuki, Hiroko. / A reticuloendothelial system-activating glycan from the roots of Astragalus membranaceus. In: Phytochemistry. 1991 ; Vol. 31, No. 1. pp. 63-66.
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