A retrospective analysis of computed tomography findings in patients with pulmonary complications after allogeneic hematopoietic stem cell transplantation

Tomotaka Ugai, Kohei Hamamoto, Shun Ichi Kimura, Yu Akahoshi, Hirofumi Nakano, Naonori Harada, Kazuaki Kameda, Hidenori Wada, Ryoko Yamasaki, Yuko Ishihara, Koji Kawamura, Kana Sakamoto, Masahiro Ashizawa, Miki Sato, Kiriko Terasako-Saito, Hideki Nakasone, Misato Kikuchi, Rie Yamazaki, Tomohisa Okochi, Junya KandaShinichi Kako, Osamu Tanaka, Yoshinobu Kanda

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective The purpose of this study was to review the high-resolution computed tomography (CT) findings in patients with pulmonary complications after allogeneic hematopoietic stem cell transplantation (HSCT), and to evaluate the relationship between CT findings and clinical outcomes. Patients and methods We collected the clinical data in 96 consecutive patients who underwent CT scan for pulmonary complications after allogeneic HSCT and analyzed the relationships among these clinical characteristics, CT findings and clinical responses. Radiologists who were blinded to clinical information evaluated the CT findings. Results In multivariate analyses, the presence of chronic graft-versus-host disease (GVHD) and non-segmental multiple consolidations were significantly associated with a poor response to antimicrobial therapies, and the disease risk was significantly associated with a poor corticosteroid response. In addition, the existence of cavity formation and pleural effusion were significantly associated with a fatal prognosis. Twenty-five patients underwent bronchoscopic examination and 4 of them also underwent transbronchial lung biopsy (TBLB), but diagnostic information was not obtained in 15 patients. There was no significant association between specific CT findings and the diagnosis based on bronchoscopic examination. Conclusions No specific CT finding was identified as a predictor for either an antimicrobial response or for a corticosteroid response in this study. The presence of cavity formation and pleural effusion may predict a poor prognosis.

Original languageEnglish
Pages (from-to)2663-2670
Number of pages8
JournalEuropean Journal of Radiology
Volume84
Issue number12
DOIs
Publication statusPublished - 2015 Jan 1
Externally publishedYes

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Hematopoietic Stem Cell Transplantation
Tomography
Lung
Pleural Effusion
Adrenal Cortex Hormones
Graft vs Host Disease
Multivariate Analysis
Biopsy

Keywords

  • CT findings
  • Hematopoietic transplantation
  • Pulmonary complication

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

A retrospective analysis of computed tomography findings in patients with pulmonary complications after allogeneic hematopoietic stem cell transplantation. / Ugai, Tomotaka; Hamamoto, Kohei; Kimura, Shun Ichi; Akahoshi, Yu; Nakano, Hirofumi; Harada, Naonori; Kameda, Kazuaki; Wada, Hidenori; Yamasaki, Ryoko; Ishihara, Yuko; Kawamura, Koji; Sakamoto, Kana; Ashizawa, Masahiro; Sato, Miki; Terasako-Saito, Kiriko; Nakasone, Hideki; Kikuchi, Misato; Yamazaki, Rie; Okochi, Tomohisa; Kanda, Junya; Kako, Shinichi; Tanaka, Osamu; Kanda, Yoshinobu.

In: European Journal of Radiology, Vol. 84, No. 12, 01.01.2015, p. 2663-2670.

Research output: Contribution to journalArticle

Ugai, T, Hamamoto, K, Kimura, SI, Akahoshi, Y, Nakano, H, Harada, N, Kameda, K, Wada, H, Yamasaki, R, Ishihara, Y, Kawamura, K, Sakamoto, K, Ashizawa, M, Sato, M, Terasako-Saito, K, Nakasone, H, Kikuchi, M, Yamazaki, R, Okochi, T, Kanda, J, Kako, S, Tanaka, O & Kanda, Y 2015, 'A retrospective analysis of computed tomography findings in patients with pulmonary complications after allogeneic hematopoietic stem cell transplantation', European Journal of Radiology, vol. 84, no. 12, pp. 2663-2670. https://doi.org/10.1016/j.ejrad.2015.08.020
Ugai, Tomotaka ; Hamamoto, Kohei ; Kimura, Shun Ichi ; Akahoshi, Yu ; Nakano, Hirofumi ; Harada, Naonori ; Kameda, Kazuaki ; Wada, Hidenori ; Yamasaki, Ryoko ; Ishihara, Yuko ; Kawamura, Koji ; Sakamoto, Kana ; Ashizawa, Masahiro ; Sato, Miki ; Terasako-Saito, Kiriko ; Nakasone, Hideki ; Kikuchi, Misato ; Yamazaki, Rie ; Okochi, Tomohisa ; Kanda, Junya ; Kako, Shinichi ; Tanaka, Osamu ; Kanda, Yoshinobu. / A retrospective analysis of computed tomography findings in patients with pulmonary complications after allogeneic hematopoietic stem cell transplantation. In: European Journal of Radiology. 2015 ; Vol. 84, No. 12. pp. 2663-2670.
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T1 - A retrospective analysis of computed tomography findings in patients with pulmonary complications after allogeneic hematopoietic stem cell transplantation

AU - Ugai, Tomotaka

AU - Hamamoto, Kohei

AU - Kimura, Shun Ichi

AU - Akahoshi, Yu

AU - Nakano, Hirofumi

AU - Harada, Naonori

AU - Kameda, Kazuaki

AU - Wada, Hidenori

AU - Yamasaki, Ryoko

AU - Ishihara, Yuko

AU - Kawamura, Koji

AU - Sakamoto, Kana

AU - Ashizawa, Masahiro

AU - Sato, Miki

AU - Terasako-Saito, Kiriko

AU - Nakasone, Hideki

AU - Kikuchi, Misato

AU - Yamazaki, Rie

AU - Okochi, Tomohisa

AU - Kanda, Junya

AU - Kako, Shinichi

AU - Tanaka, Osamu

AU - Kanda, Yoshinobu

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Objective The purpose of this study was to review the high-resolution computed tomography (CT) findings in patients with pulmonary complications after allogeneic hematopoietic stem cell transplantation (HSCT), and to evaluate the relationship between CT findings and clinical outcomes. Patients and methods We collected the clinical data in 96 consecutive patients who underwent CT scan for pulmonary complications after allogeneic HSCT and analyzed the relationships among these clinical characteristics, CT findings and clinical responses. Radiologists who were blinded to clinical information evaluated the CT findings. Results In multivariate analyses, the presence of chronic graft-versus-host disease (GVHD) and non-segmental multiple consolidations were significantly associated with a poor response to antimicrobial therapies, and the disease risk was significantly associated with a poor corticosteroid response. In addition, the existence of cavity formation and pleural effusion were significantly associated with a fatal prognosis. Twenty-five patients underwent bronchoscopic examination and 4 of them also underwent transbronchial lung biopsy (TBLB), but diagnostic information was not obtained in 15 patients. There was no significant association between specific CT findings and the diagnosis based on bronchoscopic examination. Conclusions No specific CT finding was identified as a predictor for either an antimicrobial response or for a corticosteroid response in this study. The presence of cavity formation and pleural effusion may predict a poor prognosis.

AB - Objective The purpose of this study was to review the high-resolution computed tomography (CT) findings in patients with pulmonary complications after allogeneic hematopoietic stem cell transplantation (HSCT), and to evaluate the relationship between CT findings and clinical outcomes. Patients and methods We collected the clinical data in 96 consecutive patients who underwent CT scan for pulmonary complications after allogeneic HSCT and analyzed the relationships among these clinical characteristics, CT findings and clinical responses. Radiologists who were blinded to clinical information evaluated the CT findings. Results In multivariate analyses, the presence of chronic graft-versus-host disease (GVHD) and non-segmental multiple consolidations were significantly associated with a poor response to antimicrobial therapies, and the disease risk was significantly associated with a poor corticosteroid response. In addition, the existence of cavity formation and pleural effusion were significantly associated with a fatal prognosis. Twenty-five patients underwent bronchoscopic examination and 4 of them also underwent transbronchial lung biopsy (TBLB), but diagnostic information was not obtained in 15 patients. There was no significant association between specific CT findings and the diagnosis based on bronchoscopic examination. Conclusions No specific CT finding was identified as a predictor for either an antimicrobial response or for a corticosteroid response in this study. The presence of cavity formation and pleural effusion may predict a poor prognosis.

KW - CT findings

KW - Hematopoietic transplantation

KW - Pulmonary complication

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