A reversible near-infrared fluorescence probe for reactive oxygen species based on Te-rhodamine

Yuichiro Koide, Mitsuyasu Kawaguchi, Yasuteru Urano, Kenjiro Hanaoka, Toru Komatsu, Masahiro Abo, Takuya Terai, Tetsuo Nagano

Research output: Contribution to journalArticlepeer-review

115 Citations (Scopus)

Abstract

We have designed and synthesized a reversible near-infrared (NIR) fluorescence probe, 2-Me TeR, for reactive oxygen species (ROS), utilizing the redox properties of the tellurium (Te) atom. 2-Me TeR is oxidized to fluorescent 2-Me TeOR by various ROS, while the generated 2-Me TeOR is quickly reduced in the presence of glutathione to regenerate 2-Me TeR. This redox-induced reversible NIR-fluorescence response of 2-Me TeR allowed us to detect the endogenous production of ROS and subsequent homeostatic recovery of the intracellular reductive environment in hydrogen peroxide-stimulated HL-60 cells. This probe is expected to be useful for monitoring the dynamics of ROS production continuously in vivo

Original languageEnglish
Pages (from-to)3091-3093
Number of pages3
JournalChemical Communications
Volume48
Issue number25
DOIs
Publication statusPublished - 2012 Feb 27
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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