A reversible near-infrared fluorescence probe for reactive oxygen species based on Te-rhodamine

Yuichiro Koide; Mitsuyasu Kawaguchi; Yasuteru Urano; Kenjiro Hanaoka; Toru Komatsu; Masahiro Abo; Takuya Terai; Tetsuo Nagano

doi:10.1039/c2cc18011a

A reversible near-infrared fluorescence probe for reactive oxygen species based on Te-rhodamine

Yuichiro Koide, Mitsuyasu Kawaguchi, Yasuteru Urano, Kenjiro Hanaoka, Toru Komatsu, Masahiro Abo, Takuya Terai, Tetsuo Nagano

Research output: Contribution to journal › Article › peer-review

126 Citations (Scopus)

Abstract

We have designed and synthesized a reversible near-infrared (NIR) fluorescence probe, 2-Me TeR, for reactive oxygen species (ROS), utilizing the redox properties of the tellurium (Te) atom. 2-Me TeR is oxidized to fluorescent 2-Me TeOR by various ROS, while the generated 2-Me TeOR is quickly reduced in the presence of glutathione to regenerate 2-Me TeR. This redox-induced reversible NIR-fluorescence response of 2-Me TeR allowed us to detect the endogenous production of ROS and subsequent homeostatic recovery of the intracellular reductive environment in hydrogen peroxide-stimulated HL-60 cells. This probe is expected to be useful for monitoring the dynamics of ROS production continuously in vivo

Original language	English
Pages (from-to)	3091-3093
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	25
DOIs	https://doi.org/10.1039/c2cc18011a
Publication status	Published - 2012 Feb 27
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c2cc18011a

Cite this

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abstract = "We have designed and synthesized a reversible near-infrared (NIR) fluorescence probe, 2-Me TeR, for reactive oxygen species (ROS), utilizing the redox properties of the tellurium (Te) atom. 2-Me TeR is oxidized to fluorescent 2-Me TeOR by various ROS, while the generated 2-Me TeOR is quickly reduced in the presence of glutathione to regenerate 2-Me TeR. This redox-induced reversible NIR-fluorescence response of 2-Me TeR allowed us to detect the endogenous production of ROS and subsequent homeostatic recovery of the intracellular reductive environment in hydrogen peroxide-stimulated HL-60 cells. This probe is expected to be useful for monitoring the dynamics of ROS production continuously in vivo",

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AU - Koide, Yuichiro

AU - Kawaguchi, Mitsuyasu

AU - Urano, Yasuteru

AU - Hanaoka, Kenjiro

AU - Komatsu, Toru

AU - Abo, Masahiro

AU - Terai, Takuya

AU - Nagano, Tetsuo

PY - 2012/2/27

Y1 - 2012/2/27

N2 - We have designed and synthesized a reversible near-infrared (NIR) fluorescence probe, 2-Me TeR, for reactive oxygen species (ROS), utilizing the redox properties of the tellurium (Te) atom. 2-Me TeR is oxidized to fluorescent 2-Me TeOR by various ROS, while the generated 2-Me TeOR is quickly reduced in the presence of glutathione to regenerate 2-Me TeR. This redox-induced reversible NIR-fluorescence response of 2-Me TeR allowed us to detect the endogenous production of ROS and subsequent homeostatic recovery of the intracellular reductive environment in hydrogen peroxide-stimulated HL-60 cells. This probe is expected to be useful for monitoring the dynamics of ROS production continuously in vivo

AB - We have designed and synthesized a reversible near-infrared (NIR) fluorescence probe, 2-Me TeR, for reactive oxygen species (ROS), utilizing the redox properties of the tellurium (Te) atom. 2-Me TeR is oxidized to fluorescent 2-Me TeOR by various ROS, while the generated 2-Me TeOR is quickly reduced in the presence of glutathione to regenerate 2-Me TeR. This redox-induced reversible NIR-fluorescence response of 2-Me TeR allowed us to detect the endogenous production of ROS and subsequent homeostatic recovery of the intracellular reductive environment in hydrogen peroxide-stimulated HL-60 cells. This probe is expected to be useful for monitoring the dynamics of ROS production continuously in vivo

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A reversible near-infrared fluorescence probe for reactive oxygen species based on Te-rhodamine

Abstract

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