A review of 79 thymomas: Modification of staging system and reappraisal of conventional division into invasive and non-invasive thymona

K. Koga, Y. Matsuno, M. Noguchi, K. Mukai, Hisao Asamura, T. Goya, Y. Shimosato

Research output: Contribution to journalArticle

241 Citations (Scopus)

Abstract

A clinicopathological study of surgically resected thymomas was performed using Masaoka's staging and modified Masaoka's staging systems, and the utility of these two staging systems was compared. The modification enabled adjustment for the disproportion in the number of cases between Stage I and Stage II. Analysis of survival rates, according to the tumor stage, indicated that the old classification should be reappraised, that is, division into non-invasive and invasive thymomas, although staging may contribute to the indication for postoperative radiotherapy, especially for Stage II disease. Analysis of the cases showed a wide spectrum of aggressiveness, varying from cases showing slow progression with a relatively favorable prognosis, such as the spindle cell type, to cases with rapid progression leading to tumor death in a relatively short time, such as the epithelial cell predominant and polygonal cell type. The pathological stage at the time of first surgical resection would reflect the degree of aggressiveness of thymoma in many instances. Therefore, not only staging the tumor extent but also grading of its aggressiveness are needed in order to predict the prognosis of patients with thymoma. For the latter, histology and cytopathology are helpful.

Original languageEnglish
Pages (from-to)359-367
Number of pages9
JournalPathology International
Volume44
Issue number5
Publication statusPublished - 1994
Externally publishedYes

Fingerprint

Thymoma
Neoplasm Staging
Neoplasms
Histology
Radiotherapy
Survival Rate
Epithelial Cells

Keywords

  • histopathology
  • prognostic factors
  • staging system
  • thymona

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

A review of 79 thymomas : Modification of staging system and reappraisal of conventional division into invasive and non-invasive thymona. / Koga, K.; Matsuno, Y.; Noguchi, M.; Mukai, K.; Asamura, Hisao; Goya, T.; Shimosato, Y.

In: Pathology International, Vol. 44, No. 5, 1994, p. 359-367.

Research output: Contribution to journalArticle

Koga, K. ; Matsuno, Y. ; Noguchi, M. ; Mukai, K. ; Asamura, Hisao ; Goya, T. ; Shimosato, Y. / A review of 79 thymomas : Modification of staging system and reappraisal of conventional division into invasive and non-invasive thymona. In: Pathology International. 1994 ; Vol. 44, No. 5. pp. 359-367.
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