A rheostat for immune responses: The unique properties of PD-1 and their advantages for clinical application

Taku Okazaki, Shunsuke Chikuma, Yoshiko Iwai, Sidonia Fagarasan, Tasuku Honjo

Research output: Contribution to journalArticle

406 Citations (Scopus)

Abstract

PD-1, a negative coreceptor expressed on antigen-stimulated T cells and B cells, seems to serve as a 'rheostat' of the immune response. The molecular mechanisms of the functions of PD-1, in conjunction with the mild, chronic and strain-specific autoimmune phenotypes of PD-1-deficient mice, in contrast to the devastating fatal autoimmune disease of mice deficient in the immunomodulatory receptor CTLA-4, suggest that immunoregulation by PD-1 is rather antigen specific and is mainly cell intrinsic. Such unique properties make PD-1 a powerful target for immunological therapy, with highly effective clinical applications for cancer treatment.

Original languageEnglish
Pages (from-to)1212-1218
Number of pages7
JournalNature Immunology
Volume14
Issue number12
DOIs
Publication statusPublished - 2013 Dec
Externally publishedYes

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Antigens
Autoimmune Diseases
B-Lymphocytes
T-Lymphocytes
Phenotype
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Immunology

Cite this

A rheostat for immune responses : The unique properties of PD-1 and their advantages for clinical application. / Okazaki, Taku; Chikuma, Shunsuke; Iwai, Yoshiko; Fagarasan, Sidonia; Honjo, Tasuku.

In: Nature Immunology, Vol. 14, No. 12, 12.2013, p. 1212-1218.

Research output: Contribution to journalArticle

Okazaki, Taku ; Chikuma, Shunsuke ; Iwai, Yoshiko ; Fagarasan, Sidonia ; Honjo, Tasuku. / A rheostat for immune responses : The unique properties of PD-1 and their advantages for clinical application. In: Nature Immunology. 2013 ; Vol. 14, No. 12. pp. 1212-1218.
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