A role for Cajal-retzius cells and reelin in the development of hippocampal connections

José A. Del Río, Bernd Heimrich, Víctor Borrell, Eckart Förster, Alexander Drakew, Soledad Alcántara, Kazunori Nakajima, Takaki Miyata, Masaharu Ogawa, Katsuhiko Mikoshiba, Paul Derer, Michael Frotscher, Eduardo Soriano

Research output: Contribution to journalArticle

377 Citations (Scopus)

Abstract

DURING development of the nervous system, specific recognition molecules provide the cues necessary for the formation of neural connections. In some regions, guiding cues for axonal pathfinding and target selection are provided by specific cells that exist only transiently during development, such as the floorplate or the cortical subplate. In the hippocampus, distinct groups of fibres innervate different layers. We have tested the hypothesis that transient neurons in the hippocampus provide positional information for the targeting of these fibres. Here we report that ablation of Cajal-Retzius cells in organotypic slice cultures of hippocampus prevented the ingrowth of entorhinal but not of commissural afferents. Experiments inhibiting Reelin (an extracellular matrix protein expressed by Cajal-Retzius cells) and analysis of reeler mutant mice showed dramatic abnormalities in the development of entorhinal afferents. Thus Cajal-Retzius cells and reelin are essential for the formation of layer-specific hippocampal connections.

Original languageEnglish
Pages (from-to)70-74
Number of pages5
JournalNature
Volume385
Issue number6611
DOIs
Publication statusPublished - 1997 Jan 2
Externally publishedYes

Fingerprint

Hippocampus
Cues
Neurologic Mutant Mice
Extracellular Matrix Proteins
Nervous System
Neurons
Recognition (Psychology)
Axon Guidance

ASJC Scopus subject areas

  • General

Cite this

Del Río, J. A., Heimrich, B., Borrell, V., Förster, E., Drakew, A., Alcántara, S., ... Soriano, E. (1997). A role for Cajal-retzius cells and reelin in the development of hippocampal connections. Nature, 385(6611), 70-74. https://doi.org/10.1038/385070a0

A role for Cajal-retzius cells and reelin in the development of hippocampal connections. / Del Río, José A.; Heimrich, Bernd; Borrell, Víctor; Förster, Eckart; Drakew, Alexander; Alcántara, Soledad; Nakajima, Kazunori; Miyata, Takaki; Ogawa, Masaharu; Mikoshiba, Katsuhiko; Derer, Paul; Frotscher, Michael; Soriano, Eduardo.

In: Nature, Vol. 385, No. 6611, 02.01.1997, p. 70-74.

Research output: Contribution to journalArticle

Del Río, JA, Heimrich, B, Borrell, V, Förster, E, Drakew, A, Alcántara, S, Nakajima, K, Miyata, T, Ogawa, M, Mikoshiba, K, Derer, P, Frotscher, M & Soriano, E 1997, 'A role for Cajal-retzius cells and reelin in the development of hippocampal connections', Nature, vol. 385, no. 6611, pp. 70-74. https://doi.org/10.1038/385070a0
Del Río JA, Heimrich B, Borrell V, Förster E, Drakew A, Alcántara S et al. A role for Cajal-retzius cells and reelin in the development of hippocampal connections. Nature. 1997 Jan 2;385(6611):70-74. https://doi.org/10.1038/385070a0
Del Río, José A. ; Heimrich, Bernd ; Borrell, Víctor ; Förster, Eckart ; Drakew, Alexander ; Alcántara, Soledad ; Nakajima, Kazunori ; Miyata, Takaki ; Ogawa, Masaharu ; Mikoshiba, Katsuhiko ; Derer, Paul ; Frotscher, Michael ; Soriano, Eduardo. / A role for Cajal-retzius cells and reelin in the development of hippocampal connections. In: Nature. 1997 ; Vol. 385, No. 6611. pp. 70-74.
@article{ea5eff30e6af49ad9acbdb58b1ac366f,
title = "A role for Cajal-retzius cells and reelin in the development of hippocampal connections",
abstract = "DURING development of the nervous system, specific recognition molecules provide the cues necessary for the formation of neural connections. In some regions, guiding cues for axonal pathfinding and target selection are provided by specific cells that exist only transiently during development, such as the floorplate or the cortical subplate. In the hippocampus, distinct groups of fibres innervate different layers. We have tested the hypothesis that transient neurons in the hippocampus provide positional information for the targeting of these fibres. Here we report that ablation of Cajal-Retzius cells in organotypic slice cultures of hippocampus prevented the ingrowth of entorhinal but not of commissural afferents. Experiments inhibiting Reelin (an extracellular matrix protein expressed by Cajal-Retzius cells) and analysis of reeler mutant mice showed dramatic abnormalities in the development of entorhinal afferents. Thus Cajal-Retzius cells and reelin are essential for the formation of layer-specific hippocampal connections.",
author = "{Del R{\'i}o}, {Jos{\'e} A.} and Bernd Heimrich and V{\'i}ctor Borrell and Eckart F{\"o}rster and Alexander Drakew and Soledad Alc{\'a}ntara and Kazunori Nakajima and Takaki Miyata and Masaharu Ogawa and Katsuhiko Mikoshiba and Paul Derer and Michael Frotscher and Eduardo Soriano",
year = "1997",
month = "1",
day = "2",
doi = "10.1038/385070a0",
language = "English",
volume = "385",
pages = "70--74",
journal = "Nature Cell Biology",
issn = "1465-7392",
publisher = "Nature Publishing Group",
number = "6611",

}

TY - JOUR

T1 - A role for Cajal-retzius cells and reelin in the development of hippocampal connections

AU - Del Río, José A.

AU - Heimrich, Bernd

AU - Borrell, Víctor

AU - Förster, Eckart

AU - Drakew, Alexander

AU - Alcántara, Soledad

AU - Nakajima, Kazunori

AU - Miyata, Takaki

AU - Ogawa, Masaharu

AU - Mikoshiba, Katsuhiko

AU - Derer, Paul

AU - Frotscher, Michael

AU - Soriano, Eduardo

PY - 1997/1/2

Y1 - 1997/1/2

N2 - DURING development of the nervous system, specific recognition molecules provide the cues necessary for the formation of neural connections. In some regions, guiding cues for axonal pathfinding and target selection are provided by specific cells that exist only transiently during development, such as the floorplate or the cortical subplate. In the hippocampus, distinct groups of fibres innervate different layers. We have tested the hypothesis that transient neurons in the hippocampus provide positional information for the targeting of these fibres. Here we report that ablation of Cajal-Retzius cells in organotypic slice cultures of hippocampus prevented the ingrowth of entorhinal but not of commissural afferents. Experiments inhibiting Reelin (an extracellular matrix protein expressed by Cajal-Retzius cells) and analysis of reeler mutant mice showed dramatic abnormalities in the development of entorhinal afferents. Thus Cajal-Retzius cells and reelin are essential for the formation of layer-specific hippocampal connections.

AB - DURING development of the nervous system, specific recognition molecules provide the cues necessary for the formation of neural connections. In some regions, guiding cues for axonal pathfinding and target selection are provided by specific cells that exist only transiently during development, such as the floorplate or the cortical subplate. In the hippocampus, distinct groups of fibres innervate different layers. We have tested the hypothesis that transient neurons in the hippocampus provide positional information for the targeting of these fibres. Here we report that ablation of Cajal-Retzius cells in organotypic slice cultures of hippocampus prevented the ingrowth of entorhinal but not of commissural afferents. Experiments inhibiting Reelin (an extracellular matrix protein expressed by Cajal-Retzius cells) and analysis of reeler mutant mice showed dramatic abnormalities in the development of entorhinal afferents. Thus Cajal-Retzius cells and reelin are essential for the formation of layer-specific hippocampal connections.

UR - http://www.scopus.com/inward/record.url?scp=0031021192&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031021192&partnerID=8YFLogxK

U2 - 10.1038/385070a0

DO - 10.1038/385070a0

M3 - Article

C2 - 8985248

AN - SCOPUS:0031021192

VL - 385

SP - 70

EP - 74

JO - Nature Cell Biology

JF - Nature Cell Biology

SN - 1465-7392

IS - 6611

ER -