A role of monocyte chemoattractant protein-4 (MCP-4)/CCL13 from chondrocytes in rheumatoid arthritis

Takuji Iwamoto, Hiroshi Okamoto, Shu Kobayashi, Katsunori Ikari, Yoshiaki Toyama, Taisuke Tomatsu, Naoyuki Kamatani, Shigeki Momohara

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We studied the role of monocyte chemoattractant (MCP)-4/CCL13 in the pathogenesis of rheumatoid arthritis (RA). MCP-4 was highly expressed in cartilage from RA patients. Interferon-γ significantly stimulated MCP-4/CCL13 production in human chondrocytes, and this effect was enhanced in combination with interleukin-1β or tumor necrosis factor-α. MCP-4/CCL13 induces the phosphorylation of extracellular signal-regulated kinase in fibroblast-like synoviocytes and activates cell proliferation, and PD98059 completely inhibits these effects. These data suggest that interferon-γ in combination with interleukin-1β/tumor necrosis factor-α activates the production of MCP-4/CCL13 from chondrocytes in RA joints, and that secreted MCP-4/CCL13 enhances fibroblast-like synoviocyte proliferation by activating the extracellular signal-regulated kinase mitogen-activated protein kinase cascade.

Original languageEnglish
Pages (from-to)4904-4912
Number of pages9
JournalFEBS Journal
Volume274
Issue number18
DOIs
Publication statusPublished - 2007 Sep

Fingerprint

Monocyte Chemoattractant Proteins
Chondrocytes
Rheumatoid Arthritis
Extracellular Signal-Regulated MAP Kinases
Fibroblasts
Interleukin-1
Interferons
Tumor Necrosis Factor-alpha
Phosphorylation
Chemotactic Factors
Cell proliferation
Cartilage
Mitogen-Activated Protein Kinases
Monocytes
Joints
Cell Proliferation

Keywords

  • Chondrocytes
  • Extracellular signal-regulated kinase (ERK)
  • Monocyte chemoattractant protein-4 (MCP-4)/CCL13
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Biochemistry

Cite this

A role of monocyte chemoattractant protein-4 (MCP-4)/CCL13 from chondrocytes in rheumatoid arthritis. / Iwamoto, Takuji; Okamoto, Hiroshi; Kobayashi, Shu; Ikari, Katsunori; Toyama, Yoshiaki; Tomatsu, Taisuke; Kamatani, Naoyuki; Momohara, Shigeki.

In: FEBS Journal, Vol. 274, No. 18, 09.2007, p. 4904-4912.

Research output: Contribution to journalArticle

Iwamoto, Takuji ; Okamoto, Hiroshi ; Kobayashi, Shu ; Ikari, Katsunori ; Toyama, Yoshiaki ; Tomatsu, Taisuke ; Kamatani, Naoyuki ; Momohara, Shigeki. / A role of monocyte chemoattractant protein-4 (MCP-4)/CCL13 from chondrocytes in rheumatoid arthritis. In: FEBS Journal. 2007 ; Vol. 274, No. 18. pp. 4904-4912.
@article{e92a776f2d204cc792e3d5260e5e43bc,
title = "A role of monocyte chemoattractant protein-4 (MCP-4)/CCL13 from chondrocytes in rheumatoid arthritis",
abstract = "We studied the role of monocyte chemoattractant (MCP)-4/CCL13 in the pathogenesis of rheumatoid arthritis (RA). MCP-4 was highly expressed in cartilage from RA patients. Interferon-γ significantly stimulated MCP-4/CCL13 production in human chondrocytes, and this effect was enhanced in combination with interleukin-1β or tumor necrosis factor-α. MCP-4/CCL13 induces the phosphorylation of extracellular signal-regulated kinase in fibroblast-like synoviocytes and activates cell proliferation, and PD98059 completely inhibits these effects. These data suggest that interferon-γ in combination with interleukin-1β/tumor necrosis factor-α activates the production of MCP-4/CCL13 from chondrocytes in RA joints, and that secreted MCP-4/CCL13 enhances fibroblast-like synoviocyte proliferation by activating the extracellular signal-regulated kinase mitogen-activated protein kinase cascade.",
keywords = "Chondrocytes, Extracellular signal-regulated kinase (ERK), Monocyte chemoattractant protein-4 (MCP-4)/CCL13, Rheumatoid arthritis",
author = "Takuji Iwamoto and Hiroshi Okamoto and Shu Kobayashi and Katsunori Ikari and Yoshiaki Toyama and Taisuke Tomatsu and Naoyuki Kamatani and Shigeki Momohara",
year = "2007",
month = "9",
doi = "10.1111/j.1742-4658.2007.06013.x",
language = "English",
volume = "274",
pages = "4904--4912",
journal = "FEBS Journal",
issn = "1742-464X",
publisher = "Wiley-Blackwell",
number = "18",

}

TY - JOUR

T1 - A role of monocyte chemoattractant protein-4 (MCP-4)/CCL13 from chondrocytes in rheumatoid arthritis

AU - Iwamoto, Takuji

AU - Okamoto, Hiroshi

AU - Kobayashi, Shu

AU - Ikari, Katsunori

AU - Toyama, Yoshiaki

AU - Tomatsu, Taisuke

AU - Kamatani, Naoyuki

AU - Momohara, Shigeki

PY - 2007/9

Y1 - 2007/9

N2 - We studied the role of monocyte chemoattractant (MCP)-4/CCL13 in the pathogenesis of rheumatoid arthritis (RA). MCP-4 was highly expressed in cartilage from RA patients. Interferon-γ significantly stimulated MCP-4/CCL13 production in human chondrocytes, and this effect was enhanced in combination with interleukin-1β or tumor necrosis factor-α. MCP-4/CCL13 induces the phosphorylation of extracellular signal-regulated kinase in fibroblast-like synoviocytes and activates cell proliferation, and PD98059 completely inhibits these effects. These data suggest that interferon-γ in combination with interleukin-1β/tumor necrosis factor-α activates the production of MCP-4/CCL13 from chondrocytes in RA joints, and that secreted MCP-4/CCL13 enhances fibroblast-like synoviocyte proliferation by activating the extracellular signal-regulated kinase mitogen-activated protein kinase cascade.

AB - We studied the role of monocyte chemoattractant (MCP)-4/CCL13 in the pathogenesis of rheumatoid arthritis (RA). MCP-4 was highly expressed in cartilage from RA patients. Interferon-γ significantly stimulated MCP-4/CCL13 production in human chondrocytes, and this effect was enhanced in combination with interleukin-1β or tumor necrosis factor-α. MCP-4/CCL13 induces the phosphorylation of extracellular signal-regulated kinase in fibroblast-like synoviocytes and activates cell proliferation, and PD98059 completely inhibits these effects. These data suggest that interferon-γ in combination with interleukin-1β/tumor necrosis factor-α activates the production of MCP-4/CCL13 from chondrocytes in RA joints, and that secreted MCP-4/CCL13 enhances fibroblast-like synoviocyte proliferation by activating the extracellular signal-regulated kinase mitogen-activated protein kinase cascade.

KW - Chondrocytes

KW - Extracellular signal-regulated kinase (ERK)

KW - Monocyte chemoattractant protein-4 (MCP-4)/CCL13

KW - Rheumatoid arthritis

UR - http://www.scopus.com/inward/record.url?scp=34548460833&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548460833&partnerID=8YFLogxK

U2 - 10.1111/j.1742-4658.2007.06013.x

DO - 10.1111/j.1742-4658.2007.06013.x

M3 - Article

C2 - 17824960

AN - SCOPUS:34548460833

VL - 274

SP - 4904

EP - 4912

JO - FEBS Journal

JF - FEBS Journal

SN - 1742-464X

IS - 18

ER -