A sample injection interface of mass spectrometry utilizing femtoliter-droplet shooter by microfluidics

Yuto Takagi, Yutaka Kazoe, Takehiko Kitamori

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

In this study, we developed fL droplet shooter as mass spectrometry (MS) interface which enabled to shoot 700 fL sample droplets into MS at kHz without sample loss by controlling their trajectories. MS signal with a frequency corresponding to the frequency of droplet shooting was obtained, therefore, MS detection at 100%-sample injection was verified. The signal intensity was enhanced 15 times that of the 8 pL droplet shooter in the previous report. The developed MS interface will contribute to ultrasmall analytical applications exploiting nanofluidics such as single-cell proteomics.

Original languageEnglish
Title of host publicationMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages58-59
Number of pages2
ISBN (Electronic)9781733419017
Publication statusPublished - 2020
Event24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 - Virtual, Online
Duration: 2020 Oct 42020 Oct 9

Publication series

NameMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020
CityVirtual, Online
Period20/10/420/10/9

Keywords

  • Droplet
  • Mass spectrometry
  • Microfluidics
  • Nanofluidics

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering
  • Chemistry(all)
  • Control and Systems Engineering

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