A serial observation of coronary thrombi in vivo by a new percutaneous transluminal coronary angioscope

K. Mizuno, A. Miyamoto, K. Isojima, A. Kurita, A. Senoo, T. Arai, Tsunenori Arai, H. Nakamura

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

This study was undertaken to observe coronary thrombus formation serially from an antegrade perspective by means of a new thin flexible angioscope that has an inflatable balloon at the distal tip and an angulation mechanism. To test its capabilities, thrombi were induced in the left anterior descending coronary artery of 11 dogs by copper coils, and the thrombi were then observed through this angioscope, which had been introduced into the coronary artery by a guide catheter. Five minutes after insertion of the copper coil, fibrin-like material and white components of the thrombi were seen massing around the copper coil. Then, thin, mixed thrombotic white and red components formed around the copper coil. At fifteen minutes after the copper coil insertion, the thrombi grew in size. Ten minutes later, the thrombi finally obstructed the coronary lumen in most dogs. The red and white appearance of these thrombi was confirmed macroscopically, and the microscopic findings of these occluding thrombi revealed a fibrinous network with platelet aggregates and blood cell coagulation. Though ordinary angiography cannot reveal the precise features of the various coronary thrombi, this new angioscope was able to discern them from the antegrade perspective. The capabilities of this angioscope, which enabled these findings, should prove helpful in evaluating the stages of human coronary thrombosis. Of additional benefit, this angioscope can be used clinically for cardiac catheterization.

Original languageEnglish
Pages (from-to)91-99
Number of pages9
JournalAngiology
Volume43
Issue number2
Publication statusPublished - 1992
Externally publishedYes

Fingerprint

Angioscopes
Thrombosis
Observation
Copper
Coronary Vessels
Dogs
Coronary Thrombosis
Blood Coagulation
Cardiac Catheterization
Fibrin
Blood Cells
Angiography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Mizuno, K., Miyamoto, A., Isojima, K., Kurita, A., Senoo, A., Arai, T., ... Nakamura, H. (1992). A serial observation of coronary thrombi in vivo by a new percutaneous transluminal coronary angioscope. Angiology, 43(2), 91-99.

A serial observation of coronary thrombi in vivo by a new percutaneous transluminal coronary angioscope. / Mizuno, K.; Miyamoto, A.; Isojima, K.; Kurita, A.; Senoo, A.; Arai, T.; Arai, Tsunenori; Nakamura, H.

In: Angiology, Vol. 43, No. 2, 1992, p. 91-99.

Research output: Contribution to journalArticle

Mizuno, K, Miyamoto, A, Isojima, K, Kurita, A, Senoo, A, Arai, T, Arai, T & Nakamura, H 1992, 'A serial observation of coronary thrombi in vivo by a new percutaneous transluminal coronary angioscope', Angiology, vol. 43, no. 2, pp. 91-99.
Mizuno K, Miyamoto A, Isojima K, Kurita A, Senoo A, Arai T et al. A serial observation of coronary thrombi in vivo by a new percutaneous transluminal coronary angioscope. Angiology. 1992;43(2):91-99.
Mizuno, K. ; Miyamoto, A. ; Isojima, K. ; Kurita, A. ; Senoo, A. ; Arai, T. ; Arai, Tsunenori ; Nakamura, H. / A serial observation of coronary thrombi in vivo by a new percutaneous transluminal coronary angioscope. In: Angiology. 1992 ; Vol. 43, No. 2. pp. 91-99.
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