A sesquiterpene quinone, 5-Epi-smenospongine, promotes TNF-α production in LPS-stimulated RAW 264.7 cells

Taiko Oda, Weifang Wang, Kazuyo Ukai, Takahiro Nakazawa, Masataka Mochizuki

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Eight sesquiterpene quinones: ilimaquinone (1), smenospongidine (3), smenospongiarine (5), smenospongine (7), and their corresponding 5-epimers 2, 4, 6, and 8, isolated from the Palauan marine sponge Hippospongia sp., were examined regarding their effects on TNF-α production in LPS-stimulated RAW 264.7 cells. 5-Epi-smenospongine (8) promoted the production of TNF-α to a level three times greater than the control at 10 μM, but compounds 1-7 did not show apparent activity. The results suggest that the cis-decaline ring and a primary amine in the benzoquinone ring are necessary for activity. This is the first study to report the modulation of TNF-α production by a sesquiterpene quinone.

Original languageEnglish
Pages (from-to)151-156
Number of pages6
JournalMarine Drugs
Volume5
Issue number4
DOIs
Publication statusPublished - 2007 Dec

Fingerprint

Sesquiterpenes
quinones
sponge
sesquiterpenoids
primary amines
benzoquinones
Quinones
Porifera
Amines
cells
benzoquinone
RAW 264.7 Cells
5-epi-smenospongine
effect
amine
1-(2-(3-methoxyphenyl)ethyl)phenoxy-3-(dimethylamino)-2-propanol
smenospongine
ilimaquinone

Keywords

  • Hippospongia sp.
  • Marine sponge
  • RAW 264.7 cells
  • Sesquiterpene quinone
  • TNF-α production

ASJC Scopus subject areas

  • Drug Discovery
  • Molecular Medicine
  • Aquatic Science

Cite this

A sesquiterpene quinone, 5-Epi-smenospongine, promotes TNF-α production in LPS-stimulated RAW 264.7 cells. / Oda, Taiko; Wang, Weifang; Ukai, Kazuyo; Nakazawa, Takahiro; Mochizuki, Masataka.

In: Marine Drugs, Vol. 5, No. 4, 12.2007, p. 151-156.

Research output: Contribution to journalArticle

Oda, Taiko ; Wang, Weifang ; Ukai, Kazuyo ; Nakazawa, Takahiro ; Mochizuki, Masataka. / A sesquiterpene quinone, 5-Epi-smenospongine, promotes TNF-α production in LPS-stimulated RAW 264.7 cells. In: Marine Drugs. 2007 ; Vol. 5, No. 4. pp. 151-156.
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