A sesquiterpene quinone, 5-Epi-smenospongine, promotes TNF-α production in LPS-stimulated RAW 264.7 cells

Taiko Oda, Weifang Wang, Kazuyo Ukai, Takahiro Nakazawa, Masataka Mochizuki

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Eight sesquiterpene quinones: ilimaquinone (1), smenospongidine (3), smenospongiarine (5), smenospongine (7), and their corresponding 5-epimers 2, 4, 6, and 8, isolated from the Palauan marine sponge Hippospongia sp., were examined regarding their effects on TNF-α production in LPS-stimulated RAW 264.7 cells. 5-Epi-smenospongine (8) promoted the production of TNF-α to a level three times greater than the control at 10 μM, but compounds 1-7 did not show apparent activity. The results suggest that the cis-decaline ring and a primary amine in the benzoquinone ring are necessary for activity. This is the first study to report the modulation of TNF-α production by a sesquiterpene quinone.

Original languageEnglish
Pages (from-to)151-156
Number of pages6
JournalMarine Drugs
Volume5
Issue number4
DOIs
Publication statusPublished - 2007 Dec

Keywords

  • Hippospongia sp.
  • Marine sponge
  • RAW 264.7 cells
  • Sesquiterpene quinone
  • TNF-α production

ASJC Scopus subject areas

  • Drug Discovery

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