A simple two-transition model for loss of infectivity of phages on exposure to organic solvent

Teruhiko Matsubara, Wakako Emoto, Katsuhiro Kawashiro

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The effect of water-miscible organic solvents on the stability of filamentous phages displaying a random peptide library was investigated. A kinetic analysis of the time course of viral infectivity indicated that the transition between the noninfectious and infectious form was directly related to the concentration of organic solvent.

Original languageEnglish
Pages (from-to)269-271
Number of pages3
JournalBiomolecular Engineering
Volume24
Issue number2
DOIs
Publication statusPublished - 2007 Jun 1

Keywords

  • 50% inhibitory dose
  • Non-aqueous media
  • Organic solvent
  • Peptide library
  • Phage display
  • Viral infectivity

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Molecular Biology

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