A simple two-transition model for loss of infectivity of phages on exposure to organic solvent

Teruhiko Matsubara; Wakako Emoto; Katsuhiro Kawashiro

doi:10.1016/j.bioeng.2007.02.002

A simple two-transition model for loss of infectivity of phages on exposure to organic solvent

Teruhiko Matsubara, Wakako Emoto, Katsuhiro Kawashiro

Department of Biosciences and Informatics

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

The effect of water-miscible organic solvents on the stability of filamentous phages displaying a random peptide library was investigated. A kinetic analysis of the time course of viral infectivity indicated that the transition between the noninfectious and infectious form was directly related to the concentration of organic solvent.

Original language	English
Pages (from-to)	269-271
Number of pages	3
Journal	Biomolecular Engineering
Volume	24
Issue number	2
DOIs	https://doi.org/10.1016/j.bioeng.2007.02.002
Publication status	Published - 2007 Jun 1

Keywords

50% inhibitory dose
Non-aqueous media
Organic solvent
Peptide library
Phage display
Viral infectivity

ASJC Scopus subject areas

Biotechnology
Bioengineering
Molecular Biology

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10.1016/j.bioeng.2007.02.002

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title = "A simple two-transition model for loss of infectivity of phages on exposure to organic solvent",

abstract = "The effect of water-miscible organic solvents on the stability of filamentous phages displaying a random peptide library was investigated. A kinetic analysis of the time course of viral infectivity indicated that the transition between the noninfectious and infectious form was directly related to the concentration of organic solvent.",

keywords = "50% inhibitory dose, Non-aqueous media, Organic solvent, Peptide library, Phage display, Viral infectivity",

author = "Teruhiko Matsubara and Wakako Emoto and Katsuhiro Kawashiro",

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AU - Kawashiro, Katsuhiro

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KW - Peptide library

KW - Phage display

KW - Viral infectivity

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