A Single Fluorescent Probe to Visualize Hydrogen Sulfide and Hydrogen Polysulfides with Different Fluorescence Signals

Wei Chen; Armando Pacheco; Yoko Takano; Jacob J. Day; Kenjiro Hanaoka; Ming Xian

doi:10.1002/anie.201604892

A Single Fluorescent Probe to Visualize Hydrogen Sulfide and Hydrogen Polysulfides with Different Fluorescence Signals

Wei Chen, Armando Pacheco, Yoko Takano, Jacob J. Day, Kenjiro Hanaoka, Ming Xian

Research output: Contribution to journal › Article › peer-review

216 Citations (Scopus)

Abstract

Hydrogen sulfide (H₂S) and hydrogen polysulfides (H₂S_n, n>1) are endogenous regulators of many physiological processes. In order to better understand the symbiotic relationship and cellular cross-talk between H₂S and H₂S_n, it is highly desirable to develop single fluorescent probes which enable dual-channel discrimination between H₂S and H₂S_n. Herein, we report the rational design, synthesis, and evaluation of the first dual-detection fluorescent probe DDP-1 that can visualize H₂S and H₂S_nwith different fluorescence signals. The probe showed high selectivity and sensitivity to H₂S and H₂S_nin aqueous media and in cells.

Original language	English
Pages (from-to)	9993-9996
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	55
Issue number	34
DOIs	https://doi.org/10.1002/anie.201604892
Publication status	Published - 2016 Aug 16
Externally published	Yes

Keywords

cyclization
fluorescence
fluorescent probes
hydrogen polysulfides
sulfides

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.201604892

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title = "A Single Fluorescent Probe to Visualize Hydrogen Sulfide and Hydrogen Polysulfides with Different Fluorescence Signals",

abstract = "Hydrogen sulfide (H2S) and hydrogen polysulfides (H2Sn, n>1) are endogenous regulators of many physiological processes. In order to better understand the symbiotic relationship and cellular cross-talk between H2S and H2Sn, it is highly desirable to develop single fluorescent probes which enable dual-channel discrimination between H2S and H2Sn. Herein, we report the rational design, synthesis, and evaluation of the first dual-detection fluorescent probe DDP-1 that can visualize H2S and H2Snwith different fluorescence signals. The probe showed high selectivity and sensitivity to H2S and H2Snin aqueous media and in cells.",

keywords = "cyclization, fluorescence, fluorescent probes, hydrogen polysulfides, sulfides",

author = "Wei Chen and Armando Pacheco and Yoko Takano and Day, {Jacob J.} and Kenjiro Hanaoka and Ming Xian",

note = "Funding Information: This work is supported by NIH (grant number R01HL116571). Publisher Copyright: {\textcopyright} 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",

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month = aug,

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doi = "10.1002/anie.201604892",

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T1 - A Single Fluorescent Probe to Visualize Hydrogen Sulfide and Hydrogen Polysulfides with Different Fluorescence Signals

AU - Chen, Wei

AU - Pacheco, Armando

AU - Takano, Yoko

AU - Day, Jacob J.

AU - Hanaoka, Kenjiro

AU - Xian, Ming

PY - 2016/8/16

Y1 - 2016/8/16

N2 - Hydrogen sulfide (H2S) and hydrogen polysulfides (H2Sn, n>1) are endogenous regulators of many physiological processes. In order to better understand the symbiotic relationship and cellular cross-talk between H2S and H2Sn, it is highly desirable to develop single fluorescent probes which enable dual-channel discrimination between H2S and H2Sn. Herein, we report the rational design, synthesis, and evaluation of the first dual-detection fluorescent probe DDP-1 that can visualize H2S and H2Snwith different fluorescence signals. The probe showed high selectivity and sensitivity to H2S and H2Snin aqueous media and in cells.

AB - Hydrogen sulfide (H2S) and hydrogen polysulfides (H2Sn, n>1) are endogenous regulators of many physiological processes. In order to better understand the symbiotic relationship and cellular cross-talk between H2S and H2Sn, it is highly desirable to develop single fluorescent probes which enable dual-channel discrimination between H2S and H2Sn. Herein, we report the rational design, synthesis, and evaluation of the first dual-detection fluorescent probe DDP-1 that can visualize H2S and H2Snwith different fluorescence signals. The probe showed high selectivity and sensitivity to H2S and H2Snin aqueous media and in cells.

KW - cyclization

KW - fluorescence

KW - fluorescent probes

KW - hydrogen polysulfides

KW - sulfides

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A Single Fluorescent Probe to Visualize Hydrogen Sulfide and Hydrogen Polysulfides with Different Fluorescence Signals

Abstract

Keywords

ASJC Scopus subject areas

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