Hydrogen sulfide (H2S) and hydrogen polysulfides (H2Sn, n>1) are endogenous regulators of many physiological processes. In order to better understand the symbiotic relationship and cellular cross-talk between H2S and H2Sn, it is highly desirable to develop single fluorescent probes which enable dual-channel discrimination between H2S and H2Sn. Herein, we report the rational design, synthesis, and evaluation of the first dual-detection fluorescent probe DDP-1 that can visualize H2S and H2Snwith different fluorescence signals. The probe showed high selectivity and sensitivity to H2S and H2Snin aqueous media and in cells.
|Number of pages||4|
|Journal||Angewandte Chemie - International Edition|
|Publication status||Published - 2016 Aug 16|
- fluorescent probes
- hydrogen polysulfides
ASJC Scopus subject areas