A Single Fluorescent Probe to Visualize Hydrogen Sulfide and Hydrogen Polysulfides with Different Fluorescence Signals

Wei Chen, Armando Pacheco, Yoko Takano, Jacob J. Day, Kenjiro Hanaoka, Ming Xian

Research output: Contribution to journalArticlepeer-review

185 Citations (Scopus)

Abstract

Hydrogen sulfide (H2S) and hydrogen polysulfides (H2Sn, n>1) are endogenous regulators of many physiological processes. In order to better understand the symbiotic relationship and cellular cross-talk between H2S and H2Sn, it is highly desirable to develop single fluorescent probes which enable dual-channel discrimination between H2S and H2Sn. Herein, we report the rational design, synthesis, and evaluation of the first dual-detection fluorescent probe DDP-1 that can visualize H2S and H2Snwith different fluorescence signals. The probe showed high selectivity and sensitivity to H2S and H2Snin aqueous media and in cells.

Original languageEnglish
Pages (from-to)9993-9996
Number of pages4
JournalAngewandte Chemie - International Edition
Volume55
Issue number34
DOIs
Publication statusPublished - 2016 Aug 16
Externally publishedYes

Keywords

  • cyclization
  • fluorescence
  • fluorescent probes
  • hydrogen polysulfides
  • sulfides

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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