TY - JOUR
T1 - A single nucleotide polymorphism of the adenosine deaminase, RNA-specific gene is associated with the serum triglyceride level, abdominal circumference, and serum adiponectin concentration
AU - Oguro, Ryosuke
AU - Kamide, Kei
AU - Katsuya, Tomohiro
AU - Akasaka, Hiroshi
AU - Sugimoto, Ken
AU - Congrains, Ada
AU - Arai, Yasumichi
AU - Hirose, Nobuyoshi
AU - Saitoh, Shigeyuki
AU - Ohishi, Mitsuru
AU - Miura, Tetsuji
AU - Rakugi, Hiromi
N1 - Funding Information:
We would like to express our gratitude to Ms. Yuki Imaizumi and Ms. Takako Baba for their continuous support of this investigation. This study was supported in part by grants-in-aid from the Program for Promotion of Fundamental Studies in National Institute of Biomedical Innovation of Japan (HR: 22-2-5 ), the Ministry of Education, Culture, Sports, Science, and Technology of Japan (KK: 22510211 ), and NOVARTIS Foundation for Gerontological Research (KK).
PY - 2012/2
Y1 - 2012/2
N2 - Background: Single nucleotide polymorphisms (SNPs) of the adenosine deaminase, RNA-specific (ADAR) gene were reported to be associated with human longevity. There are possibilities that ADAR is associated with major risk factors of atherosclerotic cardiovascular diseases (CVD), such as hypertension, diabetes, dyslipidemia, and obesity. Objective: To investigate the association between SNPs of the ADAR gene and clinical data associated with major risk factors of atherosclerotic CVD. Subjects: A total of 1504 general population residents (586 males and 918 females) of two towns, Tanno-cho and Sobestu-cho, in Hokkaido, Japan. Methods: Clinical data associated with risk factors of atherosclerotic CVD were collected from these study subjects. DNA from peripheral blood and written informed consent were obtained. Three single nucleotide polymorphisms of . ADARB1 and . ADARB2, which were previously reported to be associated with longevity, were genotyped employing the TaqMan PCR method. The associations between SNPs in . ADARB1 and . ADARB2 and clinical parameters related to risk factors of atherosclerosis were analyzed. Results: On uni- and multivariate analyses, rs2805533 in . ADARB2 was significantly associated with the abdominal circumference, body mass index, serum triglyceride level, and serum adiponectin level. The subjects with the AA genotype of rs2805533 had a greater abdominal circumference, higher body mass index, higher triglyceride level, and lower adiponectin level than those with AG and GG genotypes. Conclusion: The SNP in . ADARB2 related to longevity is associated with metabolic disorders. This finding suggests that genetic factors modulate human longevity via the regulation of metabolic factors such as abdominal obesity and lipid profiles.
AB - Background: Single nucleotide polymorphisms (SNPs) of the adenosine deaminase, RNA-specific (ADAR) gene were reported to be associated with human longevity. There are possibilities that ADAR is associated with major risk factors of atherosclerotic cardiovascular diseases (CVD), such as hypertension, diabetes, dyslipidemia, and obesity. Objective: To investigate the association between SNPs of the ADAR gene and clinical data associated with major risk factors of atherosclerotic CVD. Subjects: A total of 1504 general population residents (586 males and 918 females) of two towns, Tanno-cho and Sobestu-cho, in Hokkaido, Japan. Methods: Clinical data associated with risk factors of atherosclerotic CVD were collected from these study subjects. DNA from peripheral blood and written informed consent were obtained. Three single nucleotide polymorphisms of . ADARB1 and . ADARB2, which were previously reported to be associated with longevity, were genotyped employing the TaqMan PCR method. The associations between SNPs in . ADARB1 and . ADARB2 and clinical parameters related to risk factors of atherosclerosis were analyzed. Results: On uni- and multivariate analyses, rs2805533 in . ADARB2 was significantly associated with the abdominal circumference, body mass index, serum triglyceride level, and serum adiponectin level. The subjects with the AA genotype of rs2805533 had a greater abdominal circumference, higher body mass index, higher triglyceride level, and lower adiponectin level than those with AG and GG genotypes. Conclusion: The SNP in . ADARB2 related to longevity is associated with metabolic disorders. This finding suggests that genetic factors modulate human longevity via the regulation of metabolic factors such as abdominal obesity and lipid profiles.
KW - Adenosine deaminase
KW - Adiponectin
KW - Adiposity
KW - Longevity
KW - Metabolic disorders
KW - RNA-specific gene polymorphism
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U2 - 10.1016/j.exger.2011.12.004
DO - 10.1016/j.exger.2011.12.004
M3 - Article
C2 - 22210125
AN - SCOPUS:84856222267
VL - 47
SP - 183
EP - 187
JO - Experimental Gerontology
JF - Experimental Gerontology
SN - 0531-5565
IS - 2
ER -