Abstract
Background. Hyperuricemia is a risk factor for adverse renal outcomes in patients with chronic kidney disease. This study investigated the effect of uric acid on renal function in a community-based population. Results. After adjusting for possible confounders, the eGFR change was inversely correlated with uric acid at baseline. In the multivariable analysis, the decline in eGFR was significantly more rapid in subjects with the slight increase in uric acid (males ≥5.7 mg/dL, females ≥4.4 mg/dL), and the risk for incidental renal insufficiency (eGFR <60 mL/min/1.73 m2) was increased at uric acid of ≥6.3 mg/dL in males and ≥5.5 mg/dL in females, compared with the lowest quintile. The multiple linear regression analysis revealed that the effect of uric acid on eGFR changes was significant, especially in females, those with proteinuria and diabetes and those without alcohol consumption. Conclusion. This study showed that serum uric acid is independently associated with a more rapid decline of eGFR and incident renal insufficiency, and that a slight increase within the normal range of serum uric acid might be a risk for renal damage in the general population.
| Original language | English |
|---|---|
| Pages (from-to) | 2286-2292 |
| Number of pages | 7 |
| Journal | Nephrology Dialysis Transplantation |
| Volume | 29 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2014 Dec 1 |
| Externally published | Yes |
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Keywords
- Cohort study
- Renal function
- Uric acid
ASJC Scopus subject areas
- Nephrology
- Transplantation
Cite this
A slight increase within the normal range of serum uric acid and the decline in renal function : Associations in a community-based population. / Kamei, Keita; Konta, Tsuneo; Hirayama, Atsushi; Suzuki, Kazuko; Ichikawa, Kazunobu; Fujimoto, Shouichi; Iseki, Kunitoshi; Moriyama, Toshiki; Yamagata, Kunihiro; Tsuruya, Kazuhiko; Kimura, Kenjiro; Narita, Ichiei; Kondo, Masahide; Asahi, Koichi; Watanabe, Tsuyoshi.
In: Nephrology Dialysis Transplantation, Vol. 29, No. 12, 01.12.2014, p. 2286-2292.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A slight increase within the normal range of serum uric acid and the decline in renal function
T2 - Associations in a community-based population
AU - Kamei, Keita
AU - Konta, Tsuneo
AU - Hirayama, Atsushi
AU - Suzuki, Kazuko
AU - Ichikawa, Kazunobu
AU - Fujimoto, Shouichi
AU - Iseki, Kunitoshi
AU - Moriyama, Toshiki
AU - Yamagata, Kunihiro
AU - Tsuruya, Kazuhiko
AU - Kimura, Kenjiro
AU - Narita, Ichiei
AU - Kondo, Masahide
AU - Asahi, Koichi
AU - Watanabe, Tsuyoshi
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Background. Hyperuricemia is a risk factor for adverse renal outcomes in patients with chronic kidney disease. This study investigated the effect of uric acid on renal function in a community-based population. Results. After adjusting for possible confounders, the eGFR change was inversely correlated with uric acid at baseline. In the multivariable analysis, the decline in eGFR was significantly more rapid in subjects with the slight increase in uric acid (males ≥5.7 mg/dL, females ≥4.4 mg/dL), and the risk for incidental renal insufficiency (eGFR <60 mL/min/1.73 m2) was increased at uric acid of ≥6.3 mg/dL in males and ≥5.5 mg/dL in females, compared with the lowest quintile. The multiple linear regression analysis revealed that the effect of uric acid on eGFR changes was significant, especially in females, those with proteinuria and diabetes and those without alcohol consumption. Conclusion. This study showed that serum uric acid is independently associated with a more rapid decline of eGFR and incident renal insufficiency, and that a slight increase within the normal range of serum uric acid might be a risk for renal damage in the general population.
AB - Background. Hyperuricemia is a risk factor for adverse renal outcomes in patients with chronic kidney disease. This study investigated the effect of uric acid on renal function in a community-based population. Results. After adjusting for possible confounders, the eGFR change was inversely correlated with uric acid at baseline. In the multivariable analysis, the decline in eGFR was significantly more rapid in subjects with the slight increase in uric acid (males ≥5.7 mg/dL, females ≥4.4 mg/dL), and the risk for incidental renal insufficiency (eGFR <60 mL/min/1.73 m2) was increased at uric acid of ≥6.3 mg/dL in males and ≥5.5 mg/dL in females, compared with the lowest quintile. The multiple linear regression analysis revealed that the effect of uric acid on eGFR changes was significant, especially in females, those with proteinuria and diabetes and those without alcohol consumption. Conclusion. This study showed that serum uric acid is independently associated with a more rapid decline of eGFR and incident renal insufficiency, and that a slight increase within the normal range of serum uric acid might be a risk for renal damage in the general population.
KW - Cohort study
KW - Renal function
KW - Uric acid
UR - http://www.scopus.com/inward/record.url?scp=84928161080&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84928161080&partnerID=8YFLogxK
U2 - 10.1093/ndt/gfu256
DO - 10.1093/ndt/gfu256
M3 - Article
C2 - 25061123
AN - SCOPUS:84928161080
VL - 29
SP - 2286
EP - 2292
JO - Nephrology Dialysis Transplantation
JF - Nephrology Dialysis Transplantation
SN - 0931-0509
IS - 12
ER -