A slight increase within the normal range of serum uric acid and the decline in renal function: Associations in a community-based population

Keita Kamei, Tsuneo Konta, Atsushi Hirayama, Kazuko Suzuki, Kazunobu Ichikawa, Shouichi Fujimoto, Kunitoshi Iseki, Toshiki Moriyama, Kunihiro Yamagata, Kazuhiko Tsuruya, Kenjiro Kimura, Ichiei Narita, Masahide Kondo, Koichi Asahi, Tsuyoshi Watanabe

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Abstract

Background. Hyperuricemia is a risk factor for adverse renal outcomes in patients with chronic kidney disease. This study investigated the effect of uric acid on renal function in a community-based population. Results. After adjusting for possible confounders, the eGFR change was inversely correlated with uric acid at baseline. In the multivariable analysis, the decline in eGFR was significantly more rapid in subjects with the slight increase in uric acid (males ≥5.7 mg/dL, females ≥4.4 mg/dL), and the risk for incidental renal insufficiency (eGFR <60 mL/min/1.73 m2) was increased at uric acid of ≥6.3 mg/dL in males and ≥5.5 mg/dL in females, compared with the lowest quintile. The multiple linear regression analysis revealed that the effect of uric acid on eGFR changes was significant, especially in females, those with proteinuria and diabetes and those without alcohol consumption. Conclusion. This study showed that serum uric acid is independently associated with a more rapid decline of eGFR and incident renal insufficiency, and that a slight increase within the normal range of serum uric acid might be a risk for renal damage in the general population.

Original languageEnglish
Pages (from-to)2286-2292
Number of pages7
JournalNephrology Dialysis Transplantation
Volume29
Issue number12
DOIs
Publication statusPublished - 2014 Dec 1

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Keywords

  • Cohort study
  • Renal function
  • Uric acid

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

Kamei, K., Konta, T., Hirayama, A., Suzuki, K., Ichikawa, K., Fujimoto, S., Iseki, K., Moriyama, T., Yamagata, K., Tsuruya, K., Kimura, K., Narita, I., Kondo, M., Asahi, K., & Watanabe, T. (2014). A slight increase within the normal range of serum uric acid and the decline in renal function: Associations in a community-based population. Nephrology Dialysis Transplantation, 29(12), 2286-2292. https://doi.org/10.1093/ndt/gfu256