A slight increase within the normal range of serum uric acid and the decline in renal function

Associations in a community-based population

Keita Kamei, Tsuneo Konta, Atsushi Hirayama, Kazuko Suzuki, Kazunobu Ichikawa, Shouichi Fujimoto, Kunitoshi Iseki, Toshiki Moriyama, Kunihiro Yamagata, Kazuhiko Tsuruya, Kenjiro Kimura, Ichiei Narita, Masahide Kondo, Koichi Asahi, Tsuyoshi Watanabe

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background. Hyperuricemia is a risk factor for adverse renal outcomes in patients with chronic kidney disease. This study investigated the effect of uric acid on renal function in a community-based population. Results. After adjusting for possible confounders, the eGFR change was inversely correlated with uric acid at baseline. In the multivariable analysis, the decline in eGFR was significantly more rapid in subjects with the slight increase in uric acid (males ≥5.7 mg/dL, females ≥4.4 mg/dL), and the risk for incidental renal insufficiency (eGFR <60 mL/min/1.73 m2) was increased at uric acid of ≥6.3 mg/dL in males and ≥5.5 mg/dL in females, compared with the lowest quintile. The multiple linear regression analysis revealed that the effect of uric acid on eGFR changes was significant, especially in females, those with proteinuria and diabetes and those without alcohol consumption. Conclusion. This study showed that serum uric acid is independently associated with a more rapid decline of eGFR and incident renal insufficiency, and that a slight increase within the normal range of serum uric acid might be a risk for renal damage in the general population.

Original languageEnglish
Pages (from-to)2286-2292
Number of pages7
JournalNephrology Dialysis Transplantation
Volume29
Issue number12
DOIs
Publication statusPublished - 2014 Dec 1
Externally publishedYes

Fingerprint

Uric Acid
Reference Values
Kidney
Serum
Population
Renal Insufficiency
Hyperuricemia
Chronic Renal Insufficiency
Proteinuria
Alcohol Drinking
Linear Models
Regression Analysis

Keywords

  • Cohort study
  • Renal function
  • Uric acid

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

A slight increase within the normal range of serum uric acid and the decline in renal function : Associations in a community-based population. / Kamei, Keita; Konta, Tsuneo; Hirayama, Atsushi; Suzuki, Kazuko; Ichikawa, Kazunobu; Fujimoto, Shouichi; Iseki, Kunitoshi; Moriyama, Toshiki; Yamagata, Kunihiro; Tsuruya, Kazuhiko; Kimura, Kenjiro; Narita, Ichiei; Kondo, Masahide; Asahi, Koichi; Watanabe, Tsuyoshi.

In: Nephrology Dialysis Transplantation, Vol. 29, No. 12, 01.12.2014, p. 2286-2292.

Research output: Contribution to journalArticle

Kamei, K, Konta, T, Hirayama, A, Suzuki, K, Ichikawa, K, Fujimoto, S, Iseki, K, Moriyama, T, Yamagata, K, Tsuruya, K, Kimura, K, Narita, I, Kondo, M, Asahi, K & Watanabe, T 2014, 'A slight increase within the normal range of serum uric acid and the decline in renal function: Associations in a community-based population', Nephrology Dialysis Transplantation, vol. 29, no. 12, pp. 2286-2292. https://doi.org/10.1093/ndt/gfu256
Kamei, Keita ; Konta, Tsuneo ; Hirayama, Atsushi ; Suzuki, Kazuko ; Ichikawa, Kazunobu ; Fujimoto, Shouichi ; Iseki, Kunitoshi ; Moriyama, Toshiki ; Yamagata, Kunihiro ; Tsuruya, Kazuhiko ; Kimura, Kenjiro ; Narita, Ichiei ; Kondo, Masahide ; Asahi, Koichi ; Watanabe, Tsuyoshi. / A slight increase within the normal range of serum uric acid and the decline in renal function : Associations in a community-based population. In: Nephrology Dialysis Transplantation. 2014 ; Vol. 29, No. 12. pp. 2286-2292.
@article{70acedf05dc7496bb410999685029ff9,
title = "A slight increase within the normal range of serum uric acid and the decline in renal function: Associations in a community-based population",
abstract = "Background. Hyperuricemia is a risk factor for adverse renal outcomes in patients with chronic kidney disease. This study investigated the effect of uric acid on renal function in a community-based population. Results. After adjusting for possible confounders, the eGFR change was inversely correlated with uric acid at baseline. In the multivariable analysis, the decline in eGFR was significantly more rapid in subjects with the slight increase in uric acid (males ≥5.7 mg/dL, females ≥4.4 mg/dL), and the risk for incidental renal insufficiency (eGFR <60 mL/min/1.73 m2) was increased at uric acid of ≥6.3 mg/dL in males and ≥5.5 mg/dL in females, compared with the lowest quintile. The multiple linear regression analysis revealed that the effect of uric acid on eGFR changes was significant, especially in females, those with proteinuria and diabetes and those without alcohol consumption. Conclusion. This study showed that serum uric acid is independently associated with a more rapid decline of eGFR and incident renal insufficiency, and that a slight increase within the normal range of serum uric acid might be a risk for renal damage in the general population.",
keywords = "Cohort study, Renal function, Uric acid",
author = "Keita Kamei and Tsuneo Konta and Atsushi Hirayama and Kazuko Suzuki and Kazunobu Ichikawa and Shouichi Fujimoto and Kunitoshi Iseki and Toshiki Moriyama and Kunihiro Yamagata and Kazuhiko Tsuruya and Kenjiro Kimura and Ichiei Narita and Masahide Kondo and Koichi Asahi and Tsuyoshi Watanabe",
year = "2014",
month = "12",
day = "1",
doi = "10.1093/ndt/gfu256",
language = "English",
volume = "29",
pages = "2286--2292",
journal = "Nephrology Dialysis Transplantation",
issn = "0931-0509",
publisher = "Oxford University Press",
number = "12",

}

TY - JOUR

T1 - A slight increase within the normal range of serum uric acid and the decline in renal function

T2 - Associations in a community-based population

AU - Kamei, Keita

AU - Konta, Tsuneo

AU - Hirayama, Atsushi

AU - Suzuki, Kazuko

AU - Ichikawa, Kazunobu

AU - Fujimoto, Shouichi

AU - Iseki, Kunitoshi

AU - Moriyama, Toshiki

AU - Yamagata, Kunihiro

AU - Tsuruya, Kazuhiko

AU - Kimura, Kenjiro

AU - Narita, Ichiei

AU - Kondo, Masahide

AU - Asahi, Koichi

AU - Watanabe, Tsuyoshi

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Background. Hyperuricemia is a risk factor for adverse renal outcomes in patients with chronic kidney disease. This study investigated the effect of uric acid on renal function in a community-based population. Results. After adjusting for possible confounders, the eGFR change was inversely correlated with uric acid at baseline. In the multivariable analysis, the decline in eGFR was significantly more rapid in subjects with the slight increase in uric acid (males ≥5.7 mg/dL, females ≥4.4 mg/dL), and the risk for incidental renal insufficiency (eGFR <60 mL/min/1.73 m2) was increased at uric acid of ≥6.3 mg/dL in males and ≥5.5 mg/dL in females, compared with the lowest quintile. The multiple linear regression analysis revealed that the effect of uric acid on eGFR changes was significant, especially in females, those with proteinuria and diabetes and those without alcohol consumption. Conclusion. This study showed that serum uric acid is independently associated with a more rapid decline of eGFR and incident renal insufficiency, and that a slight increase within the normal range of serum uric acid might be a risk for renal damage in the general population.

AB - Background. Hyperuricemia is a risk factor for adverse renal outcomes in patients with chronic kidney disease. This study investigated the effect of uric acid on renal function in a community-based population. Results. After adjusting for possible confounders, the eGFR change was inversely correlated with uric acid at baseline. In the multivariable analysis, the decline in eGFR was significantly more rapid in subjects with the slight increase in uric acid (males ≥5.7 mg/dL, females ≥4.4 mg/dL), and the risk for incidental renal insufficiency (eGFR <60 mL/min/1.73 m2) was increased at uric acid of ≥6.3 mg/dL in males and ≥5.5 mg/dL in females, compared with the lowest quintile. The multiple linear regression analysis revealed that the effect of uric acid on eGFR changes was significant, especially in females, those with proteinuria and diabetes and those without alcohol consumption. Conclusion. This study showed that serum uric acid is independently associated with a more rapid decline of eGFR and incident renal insufficiency, and that a slight increase within the normal range of serum uric acid might be a risk for renal damage in the general population.

KW - Cohort study

KW - Renal function

KW - Uric acid

UR - http://www.scopus.com/inward/record.url?scp=84928161080&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84928161080&partnerID=8YFLogxK

U2 - 10.1093/ndt/gfu256

DO - 10.1093/ndt/gfu256

M3 - Article

VL - 29

SP - 2286

EP - 2292

JO - Nephrology Dialysis Transplantation

JF - Nephrology Dialysis Transplantation

SN - 0931-0509

IS - 12

ER -