A successful antimicrobial therapeutic strategy for the discitis caused by Aggregatibacter actinomycetemcomitans under unknown drug susceptibility: A case report

Shunsuke Uno, Yosuke Horiuchi, Takae Uchida, Akiko Yonaha, Takanori Miyata, Eiko Nagano, Takao Kodama, Naoki Hasegawa

Research output: Contribution to journalArticle


Aggregatibacter actinomycetemcomitans is well-known as the pathogen of gingivitis or periodontitis, and discitis or vertebral osteomyelitis cases caused by this organism have rarely been reported. Ampicillin or amoxicillin has been used in the previously reported discitis cases; however, no cases have been reported that is treated with levofloxacin. We report the first published case we chose levofloxacin to treat. We failed to perform the susceptibility testing because of the poor growth and fastidious nature of the organism, and the result of susceptibility of amoxicillin was unclear. Levofloxacin, which A. actinomycetemcomitans is usually susceptible to, can be an effective alternative oral antimicrobial agent in such cases.

Original languageEnglish
JournalJournal of Infection and Chemotherapy
Publication statusAccepted/In press - 2018 Jan 1



  • Aggregatibacter actinomycetemcomitans
  • Discitis
  • Levofloxacin
  • Quinolone

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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