A suitable model for experimental liver metastasis of human colon cancer xenografts using mice with severe combined immunodeficiency

Toshiharu Furukawa, Tetsuro Kubota, Masahiko Watanabe, Hideki Nishibori, Tsong‐Hong ‐H Kuo, Yoshiro Saikawa, Sugurcj Kase, Hirokazu Tanino, Tatsuo Teramoto, Kyuya Ishibiki, Masaki Kitajima

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Abstract

Studies on liver metastasis of human colon cancer are limited because of a lack of suitable animal models. In this study, the usefulness of mice with severe combined immunodeficiency (SCID), which congenitally lack functional T and B lymphocytes, was evaluated in comparison with currently available nude mice. Three human colon cancer xenografts transplantable into nude mice were disaggregated enzymatically to obtain tumor cell suspensions, and implanted intrasplenically into SCID and nude mice. The incidence of splenic tumorigenesis and of liver metastases were significantly greater in SCID mice for all xenografts, in comparison with nude mice. In total, 33 of 36 SCID mice and 17 of 43 nude mice developed liver metastases. On the basis of this result, we conclude that SCID mice would be a more suitable model than nude mice for studying liver metastasis of human colon cancer. © 1993 Wiley‐Liss, Inc.

Original languageEnglish
Pages (from-to)64-67
Number of pages4
JournalJournal of Surgical Oncology
Volume52
Issue number1
DOIs
Publication statusPublished - 1993 Jan

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Keywords

  • SCID mouse
  • human colon cancer
  • metastasis

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Furukawa, T., Kubota, T., Watanabe, M., Nishibori, H., Kuo, TH. H., Saikawa, Y., Kase, S., Tanino, H., Teramoto, T., Ishibiki, K., & Kitajima, M. (1993). A suitable model for experimental liver metastasis of human colon cancer xenografts using mice with severe combined immunodeficiency. Journal of Surgical Oncology, 52(1), 64-67. https://doi.org/10.1002/jso.2930520117