TY - JOUR
T1 - A synthesis of (-)-deoxypodocarpic acid methyl ester via an enzymatic enantioselective hydrolysis of the key intermidiate enol ester
AU - Sugai, Takeshi
AU - Kakeya, Hideaki
AU - Ohta, Hiromichi
AU - Morooka, Mitsuo
AU - Ohba, Shigeru
PY - 1989
Y1 - 1989
N2 - (1R, 4aR, 10aS)-(-)-1-Methoxycarbonyl-1, 4a-dimethyl-1,2,3,4,4a,9,10, 10a-octahydrophenanthrene (deoxypodocarpic acid methyl ester 1), a useful intermediate for the synthesis of various diterpenes, was synthesized from (R)-(+)-6-ethoxycarbonyl-2, 6-dimethyl-1-cyclohexenyl acetate 4. The chiral starting material was prepared by the enantioselective hydrolysis of the corresponding racemate using lipase OF from Candida cylindracea.
AB - (1R, 4aR, 10aS)-(-)-1-Methoxycarbonyl-1, 4a-dimethyl-1,2,3,4,4a,9,10, 10a-octahydrophenanthrene (deoxypodocarpic acid methyl ester 1), a useful intermediate for the synthesis of various diterpenes, was synthesized from (R)-(+)-6-ethoxycarbonyl-2, 6-dimethyl-1-cyclohexenyl acetate 4. The chiral starting material was prepared by the enantioselective hydrolysis of the corresponding racemate using lipase OF from Candida cylindracea.
UR - http://www.scopus.com/inward/record.url?scp=0010507617&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0010507617&partnerID=8YFLogxK
U2 - 10.1016/S0040-4020(01)85126-7
DO - 10.1016/S0040-4020(01)85126-7
M3 - Article
AN - SCOPUS:0010507617
SN - 0040-4020
VL - 45
SP - 6135
EP - 6144
JO - Tetrahedron
JF - Tetrahedron
IS - 19
ER -