A synthesis of natural α-tocopherol intermediate

Takeshi Sugai, Naoyuki Watanabe, Hiromichi Ohta

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

(S)-(-)-6-Hydroxy-2,5,7,8-tetramethyl-2-chromanmethanol, an intermediate of natural α-tocopherol was synthesized from (S)-2-benzyloxy-2-methyl-4-pentenoic acid, which was obtained by the enzymatic hydrolysis of the corresponding racemic methyl ester.

Original languageEnglish
Pages (from-to)371-376
Number of pages6
JournalTetrahedron: Asymmetry
Volume2
Issue number5
DOIs
Publication statusPublished - 1991

Fingerprint

tocopherol
Enzymatic hydrolysis
Tocopherols
hydrolysis
esters
Esters
Hydrolysis
acids
Acids
synthesis
4-pentenoic acid
methyl-4-pentenoic acid

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Organic Chemistry
  • Materials Chemistry
  • Drug Discovery

Cite this

A synthesis of natural α-tocopherol intermediate. / Sugai, Takeshi; Watanabe, Naoyuki; Ohta, Hiromichi.

In: Tetrahedron: Asymmetry, Vol. 2, No. 5, 1991, p. 371-376.

Research output: Contribution to journalArticle

Sugai, Takeshi ; Watanabe, Naoyuki ; Ohta, Hiromichi. / A synthesis of natural α-tocopherol intermediate. In: Tetrahedron: Asymmetry. 1991 ; Vol. 2, No. 5. pp. 371-376.
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