TY - JOUR
T1 - A synthesis of (R)-(-)-mevalonolactone by the combination of enzymatic and chemical methods
AU - Sugai, Takeshi
AU - Kakeya, Hideaki
AU - Ohta, Hiromichi
N1 - Funding Information:
Z&txwlw We thank Prof. Katsuhide Okada, Yanagata University and Dr. Takashi E&&a, Japan Tobacco Coqxxa-tion, for their helpful advice. Discussion and enccuragenent fran Prof. Keisuke Suzuki ad Dr. Takashi Matsunnto, this Dqartment, is gratefully acknowledged. Financial support fran the Fujisawa Foundation was acknowledged with thanks. 'Ibis work was partly supported by a Grant-in-Aid for Scientific Research fran Japanese Ministry of Education, Science and Culture.
PY - 1990
Y1 - 1990
N2 - (R)-(-)-Mevalonolactone was synthesized starting from a chiral tertiary α-benzyloxy ester, obtained by the lipase-catalyzed enantioselective hydrolysis of the corresponding racemate, in 7 steps and 21.5% overall yield. Intramolecular Friedel-Crafts reaction of an intermediate worked well as the key-step for the new carbon-carbon bond formation.
AB - (R)-(-)-Mevalonolactone was synthesized starting from a chiral tertiary α-benzyloxy ester, obtained by the lipase-catalyzed enantioselective hydrolysis of the corresponding racemate, in 7 steps and 21.5% overall yield. Intramolecular Friedel-Crafts reaction of an intermediate worked well as the key-step for the new carbon-carbon bond formation.
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U2 - 10.1016/S0040-4020(01)81516-7
DO - 10.1016/S0040-4020(01)81516-7
M3 - Article
AN - SCOPUS:0025105636
VL - 46
SP - 3463
EP - 3468
JO - Tetrahedron
JF - Tetrahedron
SN - 0040-4020
IS - 10
ER -