A theoretical study of the detection of activated position in cerebral cortex from NIR signal

Y. Kashio, Eiji Okada

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Near infrared (NIR) spectroscopy and imaging have been applied to measure oxygenation change in the brain. Multi-channel NIR system can obtain topographic image of brain function. However poor spatial resolution due to tissue scattering is serious problem of NIR imaging. In this study, we propose a simple method to estimate the centre of the absorption change in the brain from the signal detected with multichannel NIR system. The theoretical analysis of photon measurement density functions for the adjoining source-detector pairs in multi-channel NIR system suggests that the difference in intensity between the adjoining source-detector pairs almost linearly relates with the position of the absorption perturbation. The proposed method to estimate the centre of the absorption change in the brain is evaluated by using three layered head model. The estimated position is almost consistent with the centre of the absorption change. In case where the broad absorption change occurred close to the edge of the measuring region, the estimated position tends to be shifted inward of the measuring region.

Original languageEnglish
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsB. Chance, R.R. Alfano, B.J. Tromberg, M. Tamura, E.M. Sevick-Muraka
Pages462-469
Number of pages8
Volume4250
DOIs
Publication statusPublished - 2001
EventOptical Tomography and Spectroscopy of Tissue IV - San Jose, CA, United States
Duration: 2001 Jan 212001 Jan 23

Other

OtherOptical Tomography and Spectroscopy of Tissue IV
CountryUnited States
CitySan Jose, CA
Period01/1/2101/1/23

Fingerprint

cerebral cortex
Brain
brain
Infrared radiation
Infrared imaging
Detectors
Near infrared spectroscopy
Oxygenation
Probability density function
oxygenation
detectors
Light sources
estimates
Photons
Scattering
Tissue
spatial resolution
infrared spectroscopy
perturbation
photons

Keywords

  • Brain function imaging
  • Photon measurement density function (PMDF)
  • Topographic imaging

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Kashio, Y., & Okada, E. (2001). A theoretical study of the detection of activated position in cerebral cortex from NIR signal. In B. Chance, R. R. Alfano, B. J. Tromberg, M. Tamura, & E. M. Sevick-Muraka (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4250, pp. 462-469) https://doi.org/10.1117/12.434483

A theoretical study of the detection of activated position in cerebral cortex from NIR signal. / Kashio, Y.; Okada, Eiji.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / B. Chance; R.R. Alfano; B.J. Tromberg; M. Tamura; E.M. Sevick-Muraka. Vol. 4250 2001. p. 462-469.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kashio, Y & Okada, E 2001, A theoretical study of the detection of activated position in cerebral cortex from NIR signal. in B Chance, RR Alfano, BJ Tromberg, M Tamura & EM Sevick-Muraka (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 4250, pp. 462-469, Optical Tomography and Spectroscopy of Tissue IV, San Jose, CA, United States, 01/1/21. https://doi.org/10.1117/12.434483
Kashio Y, Okada E. A theoretical study of the detection of activated position in cerebral cortex from NIR signal. In Chance B, Alfano RR, Tromberg BJ, Tamura M, Sevick-Muraka EM, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4250. 2001. p. 462-469 https://doi.org/10.1117/12.434483
Kashio, Y. ; Okada, Eiji. / A theoretical study of the detection of activated position in cerebral cortex from NIR signal. Proceedings of SPIE - The International Society for Optical Engineering. editor / B. Chance ; R.R. Alfano ; B.J. Tromberg ; M. Tamura ; E.M. Sevick-Muraka. Vol. 4250 2001. pp. 462-469
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