Stereoselective and enantiospecific total synthesis of (+)-eremantholide A (1) is described. The present total synthesis features 1) regio- and stereoselective radical carbocyclization of D-glucose-derived γ-lactone7, and 2) a nine-membered ring formation by the coupling reaction of bicyclic triflate18 and known furanone19 followed by a vinylogous aldol reaction.
|Number of pages||4|
|Publication status||Published - 1995 Feb 27|
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry