Abstract
A new diterpene, komarovispirone (1) with a spiro-octahydroindene skeleton, was isolated from Dracocephalum komarovi. The structure was elucidated by extensive analyses of spectral data. Komarovispirone (1) showed trypanocidal activity against epimastigote of Trypanosoma cruzi, the causative agent of American trypanosomiasis, with a minimum lethal concentration of 23μM.
Original language | English |
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Pages (from-to) | 531-533 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 45 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2004 Jan 12 |
Externally published | Yes |
Keywords
- Diterpene
- Dracocephalum komarovi
- Spiro lactone
- Trypanocidal activity
- Trypanosoma cruzi
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry