A trypanocidal diterpene with novel skeleton from Dracocephalum komarovi

Nahoko Uchiyama; Michiho Ito; Fumiyuki Kiuchi; Gisho Honda; Yoshio Takeda; Olimjon K. Khodzhimatov; Ozodbek A. Ashurmetov

doi:10.1016/j.tetlet.2003.10.202

A trypanocidal diterpene with novel skeleton from Dracocephalum komarovi

Nahoko Uchiyama, Michiho Ito, Fumiyuki Kiuchi, Gisho Honda, Yoshio Takeda, Olimjon K. Khodzhimatov, Ozodbek A. Ashurmetov

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

A new diterpene, komarovispirone (1) with a spiro-octahydroindene skeleton, was isolated from Dracocephalum komarovi. The structure was elucidated by extensive analyses of spectral data. Komarovispirone (1) showed trypanocidal activity against epimastigote of Trypanosoma cruzi, the causative agent of American trypanosomiasis, with a minimum lethal concentration of 23μM.

Original language	English
Pages (from-to)	531-533
Number of pages	3
Journal	Tetrahedron Letters
Volume	45
Issue number	3
DOIs	https://doi.org/10.1016/j.tetlet.2003.10.202
Publication status	Published - 2004 Jan 12
Externally published	Yes

Keywords

Diterpene
Dracocephalum komarovi
Spiro lactone
Trypanocidal activity
Trypanosoma cruzi

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2003.10.202

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title = "A trypanocidal diterpene with novel skeleton from Dracocephalum komarovi",

abstract = "A new diterpene, komarovispirone (1) with a spiro-octahydroindene skeleton, was isolated from Dracocephalum komarovi. The structure was elucidated by extensive analyses of spectral data. Komarovispirone (1) showed trypanocidal activity against epimastigote of Trypanosoma cruzi, the causative agent of American trypanosomiasis, with a minimum lethal concentration of 23μM.",

keywords = "Diterpene, Dracocephalum komarovi, Spiro lactone, Trypanocidal activity, Trypanosoma cruzi",

author = "Nahoko Uchiyama and Michiho Ito and Fumiyuki Kiuchi and Gisho Honda and Yoshio Takeda and Khodzhimatov, {Olimjon K.} and Ashurmetov, {Ozodbek A.}",

note = "Funding Information: This work was supported in part by a Grant-in-Aid for Scientific Research (No. 12576027) from the Japan Society for the Promotion of Science. We are grateful to Dr. N. Kawahara of National Institute of Health Sciences for 600 MHz NMR measurements and to Dr. N. Akimoto of Kyoto University for MS measurements.",

year = "2004",

month = jan,

day = "12",

doi = "10.1016/j.tetlet.2003.10.202",

language = "English",

volume = "45",

pages = "531--533",

journal = "Tetrahedron Letters",

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T1 - A trypanocidal diterpene with novel skeleton from Dracocephalum komarovi

AU - Uchiyama, Nahoko

AU - Ito, Michiho

AU - Kiuchi, Fumiyuki

AU - Honda, Gisho

AU - Takeda, Yoshio

AU - Khodzhimatov, Olimjon K.

AU - Ashurmetov, Ozodbek A.

N1 - Funding Information: This work was supported in part by a Grant-in-Aid for Scientific Research (No. 12576027) from the Japan Society for the Promotion of Science. We are grateful to Dr. N. Kawahara of National Institute of Health Sciences for 600 MHz NMR measurements and to Dr. N. Akimoto of Kyoto University for MS measurements.

PY - 2004/1/12

Y1 - 2004/1/12

N2 - A new diterpene, komarovispirone (1) with a spiro-octahydroindene skeleton, was isolated from Dracocephalum komarovi. The structure was elucidated by extensive analyses of spectral data. Komarovispirone (1) showed trypanocidal activity against epimastigote of Trypanosoma cruzi, the causative agent of American trypanosomiasis, with a minimum lethal concentration of 23μM.

AB - A new diterpene, komarovispirone (1) with a spiro-octahydroindene skeleton, was isolated from Dracocephalum komarovi. The structure was elucidated by extensive analyses of spectral data. Komarovispirone (1) showed trypanocidal activity against epimastigote of Trypanosoma cruzi, the causative agent of American trypanosomiasis, with a minimum lethal concentration of 23μM.

KW - Diterpene

KW - Dracocephalum komarovi

KW - Spiro lactone

KW - Trypanocidal activity

KW - Trypanosoma cruzi

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DO - 10.1016/j.tetlet.2003.10.202

M3 - Article

AN - SCOPUS:0346363697

VL - 45

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 3

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A trypanocidal diterpene with novel skeleton from Dracocephalum komarovi

Abstract

Keywords

ASJC Scopus subject areas

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