A trypanocidal diterpene with novel skeleton from Dracocephalum komarovi

Nahoko Uchiyama, Michiho Ito, Fumiyuki Kiuchi, Gisho Honda, Yoshio Takeda, Olimjon K. Khodzhimatov, Ozodbek A. Ashurmetov

Research output: Contribution to journal › Article

34 Citations (Scopus)

Abstract

A new diterpene, komarovispirone (1) with a spiro-octahydroindene skeleton, was isolated from Dracocephalum komarovi. The structure was elucidated by extensive analyses of spectral data. Komarovispirone (1) showed trypanocidal activity against epimastigote of Trypanosoma cruzi, the causative agent of American trypanosomiasis, with a minimum lethal concentration of 23μM.

Original languageEnglish
Pages (from-to)531-533
Number of pages3
JournalTetrahedron Letters
Volume45
Issue number3
DOIs
Publication statusPublished - 2004 Jan 12
Externally publishedYes

Fingerprint

Diterpenes
Skeleton
Chagas Disease
Trypanosoma cruzi
komaroviquinone

Keywords

  • Diterpene
  • Dracocephalum komarovi
  • Spiro lactone
  • Trypanocidal activity
  • Trypanosoma cruzi

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Uchiyama, N., Ito, M., Kiuchi, F., Honda, G., Takeda, Y., Khodzhimatov, O. K., & Ashurmetov, O. A. (2004). A trypanocidal diterpene with novel skeleton from Dracocephalum komarovi. Tetrahedron Letters, 45(3), 531-533. https://doi.org/10.1016/j.tetlet.2003.10.202

A trypanocidal diterpene with novel skeleton from Dracocephalum komarovi. / Uchiyama, Nahoko; Ito, Michiho; Kiuchi, Fumiyuki; Honda, Gisho; Takeda, Yoshio; Khodzhimatov, Olimjon K.; Ashurmetov, Ozodbek A.

In: Tetrahedron Letters, Vol. 45, No. 3, 12.01.2004, p. 531-533.

Research output: Contribution to journal › Article

Uchiyama, N, Ito, M, Kiuchi, F, Honda, G, Takeda, Y, Khodzhimatov, OK & Ashurmetov, OA 2004, 'A trypanocidal diterpene with novel skeleton from Dracocephalum komarovi', Tetrahedron Letters, vol. 45, no. 3, pp. 531-533. https://doi.org/10.1016/j.tetlet.2003.10.202
Uchiyama N, Ito M, Kiuchi F, Honda G, Takeda Y, Khodzhimatov OK et al. A trypanocidal diterpene with novel skeleton from Dracocephalum komarovi. Tetrahedron Letters. 2004 Jan 12;45(3):531-533. https://doi.org/10.1016/j.tetlet.2003.10.202
Uchiyama, Nahoko ; Ito, Michiho ; Kiuchi, Fumiyuki ; Honda, Gisho ; Takeda, Yoshio ; Khodzhimatov, Olimjon K. ; Ashurmetov, Ozodbek A. / A trypanocidal diterpene with novel skeleton from Dracocephalum komarovi. In: Tetrahedron Letters. 2004 ; Vol. 45, No. 3. pp. 531-533.
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