A tumor of the uterine cervix with a complex histology in a Peutz-Jeghers syndrome patient with genomic deletion of the STK11 exon 1 region

Yusuke Kobayashi, Kenta Masuda, Tokuhiro Kimura, Hiroyuki Nomura, Akira Hirasawa, Kouji Banno, Nobuyuki Susumu, Kokichi Sugano, Daisuke Aoki

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Patients with Peutz-Jeghers syndrome (PJS) have a risk of complicating malignant tumors, including cancer of the uterine cervix. Mutations in the STK11 gene have been identified as being responsible for PJS. However, the genotype-phenotype correlation in PJS is poorly understood, especially with respect to malignant tumors. Here, we report a detailed analysis of a case of a cervical tumor in a PJS patient showing a large genomic deletion in exon 1 of STK11 without human papillomavirus infection. Histological examination revealed a complex histology consisting of three components: lobular endocervical gland hyperplasia (LEGH), minimal deviation adenocarcinoma (MDA) and mucinous adenocarcinoma. Immunohistochemistry for STK11 was positive in the LEGH and MDA components, while that of the mucinous adenocarcinoma stained very faintly. These findings support a close relationship among LEGH, MDA and mucinous adenocarcinoma and imply that inactivation of STK11 may occur during progression from MDA to mucinous adenocarcinoma.

Original languageEnglish
Pages (from-to)171-177
Number of pages7
JournalFuture Oncology
Volume10
Issue number2
DOIs
Publication statusPublished - 2014 Feb

Fingerprint

Peutz-Jeghers Syndrome
Mucinous Adenocarcinoma
Cervix Uteri
Exons
Histology
Adenocarcinoma
Hyperplasia
Neoplasms
Papillomavirus Infections
Genetic Association Studies
Uterine Cervical Neoplasms
Immunohistochemistry
Mutation
Genes

Keywords

  • lobular endocervical gland hyperplasia
  • minimal deviation adenocarcinoma
  • mucinous adenocarcinoma
  • Peutz-Jeghers syndrome
  • STK11

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

A tumor of the uterine cervix with a complex histology in a Peutz-Jeghers syndrome patient with genomic deletion of the STK11 exon 1 region. / Kobayashi, Yusuke; Masuda, Kenta; Kimura, Tokuhiro; Nomura, Hiroyuki; Hirasawa, Akira; Banno, Kouji; Susumu, Nobuyuki; Sugano, Kokichi; Aoki, Daisuke.

In: Future Oncology, Vol. 10, No. 2, 02.2014, p. 171-177.

Research output: Contribution to journalArticle

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