A ureteral small cell carcinoma mixed with malignant mesodermal and ectodermal elements: A clinicopathological, morphological and immunohistochemical study

Masakazu Tsutsumi, Ken ichi Tobisu, Tadao Kakizoe, Masuzo Kamiya, Michiie Sakamoto

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

A 60-year-old male with a small cell carcinoma of the right lower ureter is presented. The tumor mainly comprised a small cell carcinoma but also included a full variety of histological types such as transitional cell carcinoma, squamous cell carcinoma, adenocarcinoma, leiomyosarcoma and chondrosarcoma. Immunohistochemical staining was positive for neuron specific enolase and cluster 1 small cell lung cancer antigen/N-CAM in the small cell carcinoma and S-100 in the chondrosarcoma component. The patient underwent a right nephroureterectomy, and received prophylactic radiation of the pelvic and para-aortic lymph node regions and cisplatin and etoposide combination chemotherapy. Eight months after the chemotherapy, a transitional cell carcinoma was found in the bladder neck, and a cystectomy with urethrectomy performed. To our knowledge, this is the second report of a small cell carcinoma originating from the ureter.

Original languageEnglish
Pages (from-to)325-329
Number of pages5
JournalJapanese journal of clinical oncology
Volume23
Issue number5
DOIs
Publication statusPublished - 1993 Oct
Externally publishedYes

Keywords

  • Carcinosarcoma
  • Cisplatin
  • Etoposide chemotherapy
  • Nephroureterectomy
  • Radiation therapy
  • Small cell carcinoma
  • Ureter

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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