A viable strategy for screening the effects of glycan heterogeneity on target organ adhesion and biodistribution in live mice

Akihiro Ogura, Sayaka Urano, Tsuyoshi Tahara, Satoshi Nozaki, Regina Sibgatullina, Kenward Vong, Takehiro Suzuki, Naoshi Dohmae, Almira Kurbangalieva, Yasuyoshi Watanabe, Katsunori Tanaka

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10 Citations (Scopus)

Abstract

This work represents the first broad study of testing diverse heterogenous glycoconjugates (7 different glycoalbumins) for their differential in vivo binding (11 different cancer cell types) in both cell- and animal-based studies. As a result, various changes in biodistribution, excretion, and even tumor adhesion were observed.

Original languageEnglish
Pages (from-to)8693-8696
Number of pages4
JournalChemical Communications
Volume54
Issue number63
DOIs
Publication statusPublished - 2018 Jan 1

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ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Ogura, A., Urano, S., Tahara, T., Nozaki, S., Sibgatullina, R., Vong, K., Suzuki, T., Dohmae, N., Kurbangalieva, A., Watanabe, Y., & Tanaka, K. (2018). A viable strategy for screening the effects of glycan heterogeneity on target organ adhesion and biodistribution in live mice. Chemical Communications, 54(63), 8693-8696. https://doi.org/10.1039/c8cc01544a