A viable strategy for screening the effects of glycan heterogeneity on target organ adhesion and biodistribution in live mice

Akihiro Ogura, Sayaka Urano, Tsuyoshi Tahara, Satoshi Nozaki, Regina Sibgatullina, Kenward Vong, Takehiro Suzuki, Naoshi Dohmae, Almira Kurbangalieva, Yasuyoshi Watanabe, Katsunori Tanaka

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

This work represents the first broad study of testing diverse heterogenous glycoconjugates (7 different glycoalbumins) for their differential in vivo binding (11 different cancer cell types) in both cell- and animal-based studies. As a result, various changes in biodistribution, excretion, and even tumor adhesion were observed.

Original languageEnglish
Pages (from-to)8693-8696
Number of pages4
JournalChemical Communications
Volume54
Issue number63
DOIs
Publication statusPublished - 2018 Jan 1
Externally publishedYes

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Glycoconjugates
Polysaccharides
Tumors
Screening
Animals
Adhesion
Cells
Testing
glycosylated serum albumin

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

A viable strategy for screening the effects of glycan heterogeneity on target organ adhesion and biodistribution in live mice. / Ogura, Akihiro; Urano, Sayaka; Tahara, Tsuyoshi; Nozaki, Satoshi; Sibgatullina, Regina; Vong, Kenward; Suzuki, Takehiro; Dohmae, Naoshi; Kurbangalieva, Almira; Watanabe, Yasuyoshi; Tanaka, Katsunori.

In: Chemical Communications, Vol. 54, No. 63, 01.01.2018, p. 8693-8696.

Research output: Contribution to journalArticle

Ogura, A, Urano, S, Tahara, T, Nozaki, S, Sibgatullina, R, Vong, K, Suzuki, T, Dohmae, N, Kurbangalieva, A, Watanabe, Y & Tanaka, K 2018, 'A viable strategy for screening the effects of glycan heterogeneity on target organ adhesion and biodistribution in live mice', Chemical Communications, vol. 54, no. 63, pp. 8693-8696. https://doi.org/10.1039/c8cc01544a
Ogura, Akihiro ; Urano, Sayaka ; Tahara, Tsuyoshi ; Nozaki, Satoshi ; Sibgatullina, Regina ; Vong, Kenward ; Suzuki, Takehiro ; Dohmae, Naoshi ; Kurbangalieva, Almira ; Watanabe, Yasuyoshi ; Tanaka, Katsunori. / A viable strategy for screening the effects of glycan heterogeneity on target organ adhesion and biodistribution in live mice. In: Chemical Communications. 2018 ; Vol. 54, No. 63. pp. 8693-8696.
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