Abstract
Side-chain modifications that respond to external stimuli provide a convenient approach to control macromolecular structure and function. Responsive modification of backbone amide structure represents a direct and powerful alternative to impact folding and function. Here, we describe a new photocaging method using histidine-directed backbone modification to selectively modify peptides and proteins at the amide N-H bond. A new vinylogous photocleavage method allows photorelease of the backbone modification and, with it, restoration of function.
Original language | English |
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Pages (from-to) | 8401-8404 |
Number of pages | 4 |
Journal | Journal of the American Chemical Society |
Volume | 140 |
Issue number | 27 |
DOIs | |
Publication status | Published - 2018 Jul 11 |
Externally published | Yes |
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)
- Biochemistry
- Colloid and Surface Chemistry