A561C polymorphism of E-selectin is associated with ischemic cerebrovascular disease in the Japanese population without diabetes mellitus and hypercholesterolemia

Hidenori Hattori, Hideki Sato, Daisuke Ito, Norio Tanahashi, Mitsuru Murata, Ikuo Saito, Kiyoaki Watanabe, Norihiro Suzuki

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

E-selectin, which is a member of the selectin superfamily of adhesion molecules, contributes to the leukocyte-endothelial cell attachments and is involved in the pathogenesis of thrombovascular diseases as a consequence. We investigated the A561C mutation in the E-selectin gene in 235 Japanese patients with ischemic cerebrovascular disease (CVD) and 301 age- and sex-matched healthy controls. Excluding the subjects with diabetes mellitus and hypercholesterolemia, the AC genotype frequencies of patients with ischemic CVD were higher than those of controls: 12.7% vs. 5.8% (P = 0.04). Our results show that E-selectin gene polymorphisms represent an increased risk for ischemic CVD in the Japanese population without diabetes mellitus and hypercholesterolemia.

Original languageEnglish
Pages (from-to)221-223
Number of pages3
JournalBrain Research
Volume1108
Issue number1
DOIs
Publication statusPublished - 2006 Sep 7

Fingerprint

Cerebrovascular Disorders
E-Selectin
Hypercholesterolemia
Diabetes Mellitus
Population
Selectins
Genes
Leukocytes
Endothelial Cells
Genotype
Mutation

Keywords

  • Atherosclerosis
  • Ischemic stroke
  • Polymorphism
  • Selectins

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology

Cite this

A561C polymorphism of E-selectin is associated with ischemic cerebrovascular disease in the Japanese population without diabetes mellitus and hypercholesterolemia. / Hattori, Hidenori; Sato, Hideki; Ito, Daisuke; Tanahashi, Norio; Murata, Mitsuru; Saito, Ikuo; Watanabe, Kiyoaki; Suzuki, Norihiro.

In: Brain Research, Vol. 1108, No. 1, 07.09.2006, p. 221-223.

Research output: Contribution to journalArticle

Hattori, Hidenori ; Sato, Hideki ; Ito, Daisuke ; Tanahashi, Norio ; Murata, Mitsuru ; Saito, Ikuo ; Watanabe, Kiyoaki ; Suzuki, Norihiro. / A561C polymorphism of E-selectin is associated with ischemic cerebrovascular disease in the Japanese population without diabetes mellitus and hypercholesterolemia. In: Brain Research. 2006 ; Vol. 1108, No. 1. pp. 221-223.
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AU - Tanahashi, Norio

AU - Murata, Mitsuru

AU - Saito, Ikuo

AU - Watanabe, Kiyoaki

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