TY - JOUR
T1 - Abdominal radical trachelectomy as a fertility-sparing procedure in women with early-stage cervical cancer in a series of 61 women
AU - Nishio, Hiroshi
AU - Fujii, Takuma
AU - Kameyama, Kaori
AU - Susumu, Nobuyuki
AU - Nakamura, Masaru
AU - Iwata, Takashi
AU - Aoki, Daisuke
N1 - Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2009/10
Y1 - 2009/10
N2 - Objective: This retrospective study was conducted as a review of a series of women who had undergone abdominal radical trachelectomy and pelvic lymphadenectomy for early-stage cervical cancer. Methods: We performed a retrospective review of patients who had undergone an abdominal radical trachelectomy. Data regarding tumor size and histology, surgical complications, recurrences, pregnancies and live births were collected and were presented as a percentage of the total number of cases. Results: A total of 61 women were followed up for a median of 27 months (range: one month - 79 months). There were six recurrences (9.8%); none of the recurrences occurred in patients with a tumor diameter of < 20 mm except in one case with adenocarcinoma. Twenty-nine women attempted to conceive; four of these women were successful. All four of these women had live births: two had preterm deliveries, and the remaining two had full-term deliveries. The cumulative pregnancy rate among the women who attempted to conceive was 13.8% (4/29). Conclusion: Among selected women with early-stage cervical cancer, especially those with a tumor diameter of < 20 mm, abdominal radical trachelectomy and pelvic lymphadenectomy is a fertility-sparing treatment option, even though the cumulative conception rate was not particularly high compared with that for women who had undergone a vaginal radical trachelectomy.
AB - Objective: This retrospective study was conducted as a review of a series of women who had undergone abdominal radical trachelectomy and pelvic lymphadenectomy for early-stage cervical cancer. Methods: We performed a retrospective review of patients who had undergone an abdominal radical trachelectomy. Data regarding tumor size and histology, surgical complications, recurrences, pregnancies and live births were collected and were presented as a percentage of the total number of cases. Results: A total of 61 women were followed up for a median of 27 months (range: one month - 79 months). There were six recurrences (9.8%); none of the recurrences occurred in patients with a tumor diameter of < 20 mm except in one case with adenocarcinoma. Twenty-nine women attempted to conceive; four of these women were successful. All four of these women had live births: two had preterm deliveries, and the remaining two had full-term deliveries. The cumulative pregnancy rate among the women who attempted to conceive was 13.8% (4/29). Conclusion: Among selected women with early-stage cervical cancer, especially those with a tumor diameter of < 20 mm, abdominal radical trachelectomy and pelvic lymphadenectomy is a fertility-sparing treatment option, even though the cumulative conception rate was not particularly high compared with that for women who had undergone a vaginal radical trachelectomy.
KW - Abdominal radical trachelectomy
KW - Cervical cancer
KW - Fertility-sparing
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U2 - 10.1016/j.ygyno.2009.06.036
DO - 10.1016/j.ygyno.2009.06.036
M3 - Article
C2 - 19646742
AN - SCOPUS:69249229516
SN - 0090-8258
VL - 115
SP - 51
EP - 55
JO - Gynecologic Oncology
JF - Gynecologic Oncology
IS - 1
ER -