Abnormal axon reflex-mediated sweating correlates with high state of anxiety in Atopic Dermatitis

Akiko Kijima, Hiroyuki Murota, Saki Matsui, Aya Takahashi, Akihiro Kimura, Shun Kitaba, Jeong Beom Lee, Ichiro Katayama

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: Sweating plays a key role in skin homeostasis, including antimicrobial and moisturizing effects, and regulation of skin surface pH. Impaired axon reflex-mediated (AXR) sweating has been observed in patients with atopic dermatitis (AD). However, the mechanism of such abnormal sudomotor axon reflex remains to be revealed. Methods: To investigate this mechanism, sudomotor function was analyzed using a quantitative sudomotor axon reflex test (acetylcholine iontophoresis) in patients with AD (n = 26) and healthy volunteers (n = 12). Correlation between sudomotor function and certain background factors, including Spielberger State Trait Anxiety Inventory score, Severity Scoring of Atopic Dermatitis (SCORAD) score, number of circulating eosinophils, and serum concentrations of thymus and activation-regulated chemokine and immunoglobulin E radioimmunosorbent test, was validated. Results: Latency time was significantly prolonged in AD (p = 0.0352), and AXR sweating volume (mg/0-5 min) was significantly lower in AD patients than in healthy controls (p = 0.0441). Direct sweating volume (mg/0-5 min) was comparable in AD patients and healthy controls. A significant correlation between the evaluation results of quantitative sudomotor axon reflex tests and certain background factors was not observed. The latency time in non-lesioned and lesioned areas for AD patients versus continuous anxiety value in the Spielberger State Trait Anxiety Inventory and the AXR versus SCORAD showed significant correlations (p = 0.0424, p = 0.0169, and p = 0.0523, respectively). Conclusions: Although the number of study subjects was little, abnormal AXR sweating in patients with AD was observed. Correlative analysis suggests possible involvement of continuous anxiety and the immune system in such abnormal sudomotor function.

Original languageEnglish
Pages (from-to)469-473
Number of pages5
JournalAllergology International
Volume61
Issue number3
DOIs
Publication statusPublished - 2012

Fingerprint

Abnormal Reflexes
Sweating
Atopic Dermatitis
Axons
Anxiety
Reflex
Radioimmunosorbent Test
Chemokine CCL17
Iontophoresis
Equipment and Supplies
Skin
Eosinophils
Immunoglobulin E
Acetylcholine
Immune System
Healthy Volunteers
Homeostasis

Keywords

  • Acetylcholine
  • Anxiety
  • Atopic dermatitis
  • Axon reflex
  • Sweating

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Kijima, A., Murota, H., Matsui, S., Takahashi, A., Kimura, A., Kitaba, S., ... Katayama, I. (2012). Abnormal axon reflex-mediated sweating correlates with high state of anxiety in Atopic Dermatitis. Allergology International, 61(3), 469-473. https://doi.org/10.2332_allergolint.12-OA-0429

Abnormal axon reflex-mediated sweating correlates with high state of anxiety in Atopic Dermatitis. / Kijima, Akiko; Murota, Hiroyuki; Matsui, Saki; Takahashi, Aya; Kimura, Akihiro; Kitaba, Shun; Lee, Jeong Beom; Katayama, Ichiro.

In: Allergology International, Vol. 61, No. 3, 2012, p. 469-473.

Research output: Contribution to journalArticle

Kijima, A, Murota, H, Matsui, S, Takahashi, A, Kimura, A, Kitaba, S, Lee, JB & Katayama, I 2012, 'Abnormal axon reflex-mediated sweating correlates with high state of anxiety in Atopic Dermatitis', Allergology International, vol. 61, no. 3, pp. 469-473. https://doi.org/10.2332_allergolint.12-OA-0429
Kijima, Akiko ; Murota, Hiroyuki ; Matsui, Saki ; Takahashi, Aya ; Kimura, Akihiro ; Kitaba, Shun ; Lee, Jeong Beom ; Katayama, Ichiro. / Abnormal axon reflex-mediated sweating correlates with high state of anxiety in Atopic Dermatitis. In: Allergology International. 2012 ; Vol. 61, No. 3. pp. 469-473.
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abstract = "Background: Sweating plays a key role in skin homeostasis, including antimicrobial and moisturizing effects, and regulation of skin surface pH. Impaired axon reflex-mediated (AXR) sweating has been observed in patients with atopic dermatitis (AD). However, the mechanism of such abnormal sudomotor axon reflex remains to be revealed. Methods: To investigate this mechanism, sudomotor function was analyzed using a quantitative sudomotor axon reflex test (acetylcholine iontophoresis) in patients with AD (n = 26) and healthy volunteers (n = 12). Correlation between sudomotor function and certain background factors, including Spielberger State Trait Anxiety Inventory score, Severity Scoring of Atopic Dermatitis (SCORAD) score, number of circulating eosinophils, and serum concentrations of thymus and activation-regulated chemokine and immunoglobulin E radioimmunosorbent test, was validated. Results: Latency time was significantly prolonged in AD (p = 0.0352), and AXR sweating volume (mg/0-5 min) was significantly lower in AD patients than in healthy controls (p = 0.0441). Direct sweating volume (mg/0-5 min) was comparable in AD patients and healthy controls. A significant correlation between the evaluation results of quantitative sudomotor axon reflex tests and certain background factors was not observed. The latency time in non-lesioned and lesioned areas for AD patients versus continuous anxiety value in the Spielberger State Trait Anxiety Inventory and the AXR versus SCORAD showed significant correlations (p = 0.0424, p = 0.0169, and p = 0.0523, respectively). Conclusions: Although the number of study subjects was little, abnormal AXR sweating in patients with AD was observed. Correlative analysis suggests possible involvement of continuous anxiety and the immune system in such abnormal sudomotor function.",
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