Abnormal Expression of Blood Group–related Antigens in Uterine Endometrial Cancers

Katsumi Tsukazaki, Motoko Sakayori, Hiroharu Arai, Kanji Yamaoka, Soju Kurihara, Shiro Nozawa

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The expression of A, B, and H group antigens, Lewis group antigens (Lewisa, Lewisb, Lewisx, and Lewisy), and Lc4 and nLc4 antigens, the precursor antigens of both groups, was examined immunohistochemically with monoclonal antibodies in 9 normal endometria, 6 endometrial hyperplasias, and 31 endometrial cancers. 1) A, B and/or H antigens were detected in endometrial cancers at an incidence of 51.6%, while no distinct localization of these antigens was observed in normal endometria. H antigen, the precursor of A and B antigens, was particularly frequently detected in endometerial cancers. 2) An increased rate of expression of Lewis group antigens, particularly Lewisb antigen, was observed in endometrial cancers compared with its expression in normal endometria. 3) Lc4 and nLc4 antigens were detected in endometrial cancers at rates of 41.9% and 38.7%, respectively, these expressions being increased compared with those in normal endometria. 4) These results suggest that a highly abnormal expression of blood group–related antigens in endometrial cancers occurs not only at the level of A, B, and H antigens and Lewis group antigens, but also at the level of their precursor Lc4 and nLc4 antigens. 5) Lewisa, Lewisb, and Lc4 antigens, built on the type–1 chain, are more specific to endometrial cancers than their respective positional isomers, Lewisx, Lewisy, and nLc4 antigens, built on the type–2 chain.

Original languageEnglish
Pages (from-to)934-941
Number of pages8
JournalJapanese Journal of Cancer Research
Volume82
Issue number8
DOIs
Publication statusPublished - 1991 Aug

Keywords

  • Blood group
  • Endometrial cancer
  • Imraunohistochemistry
  • Lc4
  • Monoclonal antibody
  • nLc4
  • related antigens

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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